Summary The vertebrate Six (Sine oculis homeobo x) family of homeodomain transcription
factors plays critical roles in the development of several organs. Six1 plays a central role in …

Cellular senescence, a stable form of cell cycle arrest, accompanied by pronounced
secretory activity, has functional roles in both physiological and pathological conditions …

Mammalian reproductive performance declines rapidly with advanced maternal age. This
effect is largely attributed to the exponential increase in chromosome segregation errors in …

Advancing age has a negative impact on female fertility. As implantation rates decline during
the normal maternal life course, age-related, embryonic factors are altered and our inability …

Can we reset, reprogram, rejuvenate, or reverse the organismal aging process? Certain
genetic manipulations could at least reset and reprogram epigenetic dynamics beyond …

While genes involved in the differentiation of the mechanosensory hair cells and the
neurons innervating them have been identified, genes involved in balancing their relative …

This work presents a comprehensive model that aims to unify our understanding of
embryogenesis, ageing, and cancer. While there have been previous attempts to construct …

The idea that aging follows a predetermined sequence of events, a program, has been
discredited by most contemporary authors. Instead, aging is largely thought to occur due to …

The developmental processes leading to the differentiation of mechanosensory hair cells
and statoacoustic ganglion neurons from the early otic epithelium remain unclear. Possible …

Background Advanced paternal age (APA) is associated with adverse outcomes to offspring
health, including increased risk for neurodevelopmental disorders. The aim of this study was …