Molecular mechanisms and clinical implications of the gold drug auranofin

S Shen, J Shen, Z Luo, F Wang, J Min - Coordination Chemistry Reviews, 2023 - Elsevier
Auranofin (AUR) is an orally available lipophilic gold-based anti-inflammatory compound
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …

Next generation gold drugs and probes: chemistry and biomedical applications

RT Mertens, S Gukathasan, AS Arojojoye… - Chemical …, 2023 - ACS Publications
The gold drugs, gold sodium thiomalate (Myocrisin), aurothioglucose (Solganal), and the
orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of …

Repurposing of the gold drug auranofin and a review of its derivatives as antibacterial therapeutics

Y Liu, Y Lu, Z Xu, X Ma, X Chen, W Liu - Drug Discovery Today, 2022 - Elsevier
Multidrug resistance (MDR) is a significant issue associated with the clinical application of
antibiotics. It is also challenging to discover and develop new antibiotics with novel …

Speciation analysis of the antirheumatic agent Auranofin and its thiol adducts by LC/ESI-MS and LC/ICP-MS

A Albert, C Brauckmann, F Blaske, M Sperling… - Journal of Analytical …, 2012 - pubs.rsc.org
Auranofin is a gold (I)-based pharmaceutical for the treatment of rheumatoid arthritis.
Despite the fact that it has been used since the 1970s, its mode of action is still not fully …

The biological activity of auranofin: implications for novel treatment of diseases

JM Madeira, DL Gibson, WF Kean, A Klegeris - Inflammopharmacology, 2012 - Springer
More than 30 years ago, auranofin was developed for the treatment of rheumatoid arthritis
as a substitution for the injectable gold compounds aurothiomalate and aurothioglucose …

Potential anticancer activity of auranofin

T Onodera, I Momose, M Kawada - Chemical and Pharmaceutical …, 2019 - jstage.jst.go.jp
Gold compounds have a long history of use in medicine. Auranofin was developed more
than 30 years ago as an oral therapy for rheumatoid arthritis. Now, however, auranofin is …

Molecular mechanisms and proposed targets for selected anticancer gold compounds

A Casini, L Messori - Current topics in medicinal chemistry, 2011 - ingentaconnect.com
Nowadays, gold compounds constitute a family of very promising experimental agents for
cancer treatment. Indeed, several gold (I) and gold (III) compounds were shown to manifest …

An investigation into the interactions of gold nanoparticles and anti-arthritic drugs with macrophages, and their reactivity towards thioredoxin reductase

LRA James, ZQ Xu, R Sluyter, EL Hawksworth… - Journal of inorganic …, 2015 - Elsevier
Gold (I) complexes are an important tool in the arsenal of established approaches for
treating rheumatoid arthritis (RA), while some recent studies have suggested that gold …

Mechanistic insights into gold organometallic compounds and their biomedical applications

S Jürgens, A Casini - Chimia, 2017 - orca.cardiff.ac.uk
The application of gold in medicine can be traced back several thousand years and Au (i)
compounds have been used in the treatment of rheumatoid arthritis since the last century …

Replacement of the thiosugar of auranofin with iodide enhances the anticancer potency in a mouse model of ovarian cancer

T Marzo, L Massai, A Pratesi, M Stefanini… - ACS Medicinal …, 2019 - ACS Publications
In recent years, a few successful attempts were made to repurpose the clinically approved
antiarthritic gold drug, Auranofin (AF), as an anticancer agent. The present study shows that …