Major depressive disorder (MDD) and bipolar disorder (BD) are psychiatric disorders with a
high morbidity and mortality. Both disease entities share in common that there are …

In the course of time, the treatment regime of bipolar disorder has changed: in mild cases of
manic and depressive episodes, monotherapeutic approaches are still commonly used …

Bipolar depression and its clinical presentation is a frequent but complex psychiatric
disease. Despite the high prevalence and the clinical and economic relevance of bipolar …

It is estimated that between 60 and 80% of those with major depressive disorder do not
achieve full symptomatic remission from first-line antidepressant monotherapy. Residual …

The development of rationalized 'combination treatment'guidelines is essential today, as it
seems that the vast majority of patients do poorly on monotherapy and need complex …

Introduction: The role of antidepressant drugs in acute and maintenance treatment of bipolar
depression is a matter of debate that cannot be decided from the evidence available in the …

Abstract Background Bipolar Disorder (BD) long-term treatment is aimed to prevent relapses
associated with worsening cognitive impairment and chronicity. Available mood stabilizers …

This paper is a systematic review of the available data concerning the treatment of bipolar
disorder: a systematic Medline search concerning treatment guidelines and clinical trials …

The drug treatment of the depressed phase of bipolar disorder has received, thus far, very
little empirical attention. In fact, most trials of antidepressant drugs have either pooled …

Background: Although many if not most patients with bipolar disorder received long-term or
maintenance treatment with multiple medications, there are very few data regarding the …