Animal and cellular models of Alzheimer's disease: Progress, promise, and future approaches
L Trujillo-Estrada, E Sanchez-Mejias… - The …, 2022 - journals.sagepub.com
Alzheimer's disease (AD) is an incurable neurodegenerative disease affecting over 45
million people worldwide. Transgenic mouse models have made remarkable contributions …
million people worldwide. Transgenic mouse models have made remarkable contributions …
Transgenic mouse models of Alzheimer disease: developing a better model as a tool for therapeutic interventions
M Kitazawa, R Medeiros… - Current pharmaceutical …, 2012 - ingentaconnect.com
Alzheimer disease (AD) is the leading cause of dementia among elderly. Currently, no
effective treatment is available for AD. Analysis of transgenic mouse models of AD has …
effective treatment is available for AD. Analysis of transgenic mouse models of AD has …
[HTML][HTML] Mammalian Models in Alzheimer's Research: An Update
A form of dementia distinct from healthy cognitive aging, Alzheimer's disease (AD) is a
complex multi-stage disease that currently afflicts over 50 million people worldwide …
complex multi-stage disease that currently afflicts over 50 million people worldwide …
Past to future: what animal models have taught us about Alzheimer's disease
AC Martini, S Forner, L Trujillo-Estrada… - Journal of …, 2018 - content.iospress.com
Alzheimer's disease (AD) impairs memory and causes significant cognitive deficits. The
disease course is prolonged, with a poor prognosis, and thus exacts an enormous economic …
disease course is prolonged, with a poor prognosis, and thus exacts an enormous economic …
[HTML][HTML] Animal models of Alzheimer's disease: preclinical insights and challenges
QQ Xu, W Yang, M Zhong, ZX Lin, NE Gray… - Acta Materia …, 2023 - scienceopen.com
Alzheimer's disease (AD), an irreversible neurodegenerative disease that progressively
impairs memory and cognitive judgment, severely affects the quality of life and imposes a …
impairs memory and cognitive judgment, severely affects the quality of life and imposes a …
[HTML][HTML] Animal models of Alzheimer's disease
G Casadesus, G Arendash, F Laferla… - International journal of …, 2010 - ncbi.nlm.nih.gov
The necessity for a deeper understanding of neurological diseases such as Alzheimer's
disease (AD) that increase in frequency as a function of age has become of paramount …
disease (AD) that increase in frequency as a function of age has become of paramount …
[HTML][HTML] A review of the current mammalian models of Alzheimer's disease and challenges that need to be overcome
NE Mckean, RR Handley, RG Snell - International journal of molecular …, 2021 - mdpi.com
Alzheimer's disease (AD) is one of the looming health crises of the near future. Increasing
lifespans and better medical treatment for other conditions mean that the prevalence of this …
lifespans and better medical treatment for other conditions mean that the prevalence of this …
Overview of transgenic mouse models for Alzheimer's disease
A Myers, P McGonigle - Current protocols in neuroscience, 2019 - Wiley Online Library
This review describes several transgenic mouse models of Alzheimer's disease (AD), a
devastating neurodegenerative disorder that causes progressive cognitive decline and is …
devastating neurodegenerative disorder that causes progressive cognitive decline and is …
Transgenic mice as a model for Alzheimer's disease
C Unger Lithner, MM Hedberg… - Current Alzheimer …, 2011 - ingentaconnect.com
During the last few decades, numerous stable transgenic mouse strains have been
developed in order to mimic a range of Alzheimer's disease (AD)-related pathologies …
developed in order to mimic a range of Alzheimer's disease (AD)-related pathologies …
Selecting a mouse model of Alzheimer's disease
J Chin - … Disease and Frontotemporal Dementia: Methods and …, 2011 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disease and cause of
dementia. Significant strides toward understanding and developing therapies for AD have …
dementia. Significant strides toward understanding and developing therapies for AD have …