Glioblastoma is a lethal brain tumor that exhibits heterogeneity and resistance to therapy.
Our understanding of tumor homeostasis is limited by a lack of genetic tools to selectively …

Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal
diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic …

Diverse genetic, epigenetic, and developmental programs drive glioblastoma, an incurable
and poorly understood tumor, but their precise characterization remains challenging. Here …

Background Despite extensive molecular characterization, we lack a comprehensive
understanding of lineage identity, differentiation, and proliferation in high-grade gliomas …

The histopathological and molecular heterogeneity of glioblastomas represents a major
obstacle for effective therapies. Glioblastomas do not develop autonomously, but evolve in a …

Glioblastoma (GBM) is an incurable primary malignant brain cancer hallmarked with a
substantial protumorigenic immune component. Knowledge of the GBM immune …

Background Multiple glioblastoma studies have described a mesenchymal (MES) state, with
each study defining the MES program by distinct sets of genes and highlighting distinct …

Glioblastoma (GBM) is the most aggressive primary brain tumor. In addition to being
genetically heterogeneous, GBMs are also immunologically heterogeneous. However …

Glioblastomas exhibit vast inter-and intra-tumoral heterogeneity, complicating the
development of effective therapeutic strategies. Current in vitro models are limited in …

Glioblastomas harbor diverse cell populations, including rare glioblastoma stem cells
(GSCs) that drive tumorigenesis. To characterize functional diversity within this population …