Mitochondrial health is based on a delicate balance of specific mitochondrial functions (eg
metabolism, signaling, dynamics) that are impaired in neurodegenerative diseases …

In recent years, multiple disciplines have focused on mitochondrial biology and contributed
to understanding its relevance towards adult-onset neurodegenerative disorders. These are …

Mitochondria function differently in aged brains than they do in young brains. Consistently
reported changes include reduced electron transport chain (ETC) enzyme activities, reduced …

Mitochondria are essential for neuronal survival and mitochondrial dysfunction is a hallmark
of neurodegeneration. The loss in mitochondrial energy production, oxidative stress, and …

Mitochondria have multiple functions such as supplying energy, regulating the redox status,
and producing proteins encoded by an independent genome. They are closely related to the …

Importance of the field: With improvements in life expectancy over the past decades, the
incidence of neurodegenerative disease has dramatically increased and new therapeutic …

Alzheimer's disease (AD) is an increasingly pressing worldwide public-health, social,
political and economic concern. Despite significant investment in multiple traditional …

Many lines of evidence have indicated the therapeutic potential of rescuing mitochondrial
integrity by targeting specific mitochondrial quality control pathways in neurodegenerative …

Mitochondria are the power engine generating biochemical energy in the cell. Mitochondrial
dysfunction and bioenergy deficiency is closely linked to the pathogenesis of …

Importance of the field: The socioeconomic burden of an aging population has accelerated
the urgency of novel therapeutic strategies for neurodegenerative disease. One possible …