Characterization of molecular mechanisms driving Merkel cell polyomavirus oncogene transcription and tumorigenic potential

JF Yang, W Liu, J You - PLoS Pathogens, 2023 - journals.plos.org
Merkel cell polyomavirus (MCPyV) is associated with approximately 80% of cases of Merkel
cell carcinoma (MCC), an aggressive type of skin cancer. The incidence of MCC has tripled …

Molecular mechanisms of merkel cell polyomavirus transformation and replication

W Liu, J You - Annual review of virology, 2020 - annualreviews.org
Viral infection underlies a significant share of the global cancer burden. Merkel cell
polyomavirus (MCPyV) is the newest member of the human oncogenic virus family. Its …

[PDF][PDF] Identifying the target cells and mechanisms of Merkel cell polyomavirus infection

W Liu, R Yang, AS Payne, RM Schowalter… - Cell host & …, 2016 - cell.com
Infection with Merkel cell polyomavirus (MCPyV) can lead to Merkel cell carcinoma (MCC), a
lethal form of skin cancer. However, the skin cell type productively infected by MCPyV …

Merkel cell polyomavirus: a new DNA virus associated with human cancer

M MacDonald, J You - Infectious Agents Associated Cancers …, 2017 - Springer
Merkel cell polyomavirus (MCPyV or MCV) is a novel human polyomavirus that has been
discovered in Merkel cell carcinoma (MCC), a highly aggressive skin cancer. MCPyV …

[HTML][HTML] Merkel cell polyomavirus and associated Merkel cell carcinoma

JF Yang, J You - Tumour Virus Research, 2022 - Elsevier
Merkel cell polyomavirus (MCPyV) is a ubiquitous skin infection that can cause Merkel cell
carcinoma (MCC), a highly lethal form of skin cancer with a nearly 50% mortality rate. Since …

Merkel cell polyomavirus downregulates N-myc downstream-regulated gene 1, leading to cellular proliferation and migration

P Gupta, N Shahzad, A Harold, M Shuda… - Journal of …, 2020 - Am Soc Microbiol
Merkel cell polyomavirus (MCPyV) is the first human polyomavirus etiologically associated
with Merkel cell carcinoma (MCC), a rare and aggressive form of skin cancer. Similar to …

Epigenetic dysregulations in merkel cell polyomavirus-driven merkel cell carcinoma

JC Rotondo, C Mazziotta, C Lanzillotti… - International Journal of …, 2021 - mdpi.com
Merkel cell polyomavirus (MCPyV) is a small DNA virus with oncogenic potential. MCPyV is
the causative agent of Merkel Cell Carcinoma (MCC), a rare but aggressive tumor of the …

Current in vitro and in vivo models to study MCPyV-associated MCC

ASW Loke, PF Lambert, ME Spurgeon - Viruses, 2022 - mdpi.com
Merkel cell polyomavirus (MCPyV) is the only human polyomavirus currently known to cause
human cancer. MCPyV is believed to be an etiological factor in at least 80% of cases of the …

Merkel cell polyomavirus infection and detection

W Liu, NA Krump, CB Buck, J You - JoVE (Journal of Visualized …, 2019 - jove.com
Merkel cell polyomavirus (MCPyV) infection can lead to Merkel cell carcinoma (MCC), a
highly aggressive form of skin cancer. Mechanistic studies to fully investigate MCPyV …

Merkel cell polyomavirus: molecular insights into the most recently discovered human tumour virus

G Stakaitytė, JJ Wood, LM Knight, H Abdul-Sada… - Cancers, 2014 - mdpi.com
A fifth of worldwide cancer cases have an infectious origin, with viral infection being the
foremost. One such cancer is Merkel cell carcinoma (MCC), a rare but aggressive skin …