Oral Immunization against PEDV with Recombinant Lactobacillus casei Expressing Dendritic Cell-Targeting Peptide Fusing COE Protein of PEDV in Piglets

X Hou, X Jiang, Y Jiang, L Tang, Y Xu, X Qiao, M Liu… - Viruses, 2018 - mdpi.com
Porcine epidemic diarrhea (PED) is a highly contagious disease in newborn piglets. In our
previous study, a genetically engineered Lactobacillus casei oral vaccine (pPG-COE …

Oral delivery of probiotics expressing dendritic cell-targeting peptide fused with porcine epidemic diarrhea virus COE antigen: a promising vaccine strategy against …

X Wang, L Wang, X Huang, S Ma, M Yu, W Shi, X Qiao… - Viruses, 2017 - mdpi.com
Porcine epidemic diarrhea virus (PEDV), an enteric coronavirus, is the causative agent of
porcine epidemic diarrhea (PED) that damages intestinal epithelial cells and results in …

Immune Responses in Pregnant Sows Induced by Recombinant Lactobacillus johnsonii Expressing the COE Protein of Porcine Epidemic Diarrhea Virus Provide …

D Zheng, X Wang, N Ju, Z Wang, L Sui, L Wang, X Qiao… - Viruses, 2021 - mdpi.com
Porcine epidemic diarrhea (PED) induced by porcine epidemic diarrhea virus (PEDV) is an
intestinal infectious disease in pigs that causes serious economic losses to the pig industry …

Oral recombinant Lactobacillus vaccine targeting the intestinal microfold cells and dendritic cells for delivering the core neutralizing epitope of porcine epidemic …

S Ma, L Wang, X Huang, X Wang, S Chen, W Shi… - Microbial Cell …, 2018 - Springer
Background Porcine epidemic diarrhea caused by porcine epidemic diarrhea virus (PEDV)
has led to serious economic losses to the swine industry worldwide. In this study, an oral …

Oral immunization with a Lactobacillus casei‐based anti‐porcine epidemic diarrhoea virus (PEDV) vaccine expressing microfold cell‐targeting peptide Co1 fused …

XN Wang, L Wang, DZ Zheng, S Chen… - Journal of applied …, 2018 - academic.oup.com
Aims The aims of this study were to develop an effective M cell‐targeting oral vaccine,
involving Lactobacillus casei to deliver the porcine epidemic diarrhoea virus (PEDV) core …

Vaccination of sows with a dendritic cell-targeted porcine epidemic diarrhea virus S1 protein-based candidate vaccine reduced viral shedding but exacerbated gross …

S Subramaniam, DM Yugo… - Journal of General …, 2018 - microbiologyresearch.org
Porcine epidemic diarrhea virus (PEDV) poses a serious threat to swine worldwide as
evidenced by its recent introduction into the USA and the devastating economic impact it …

Mucosal immune responses induced by oral administration recombinant Bacillus subtilis expressing the COE antigen of PEDV in newborn piglets

J Wang, L Huang, C Mou, E Zhang, Y Wang… - Bioscience …, 2019 - portlandpress.com
Porcine epidemic diarrhea (PED) is a highly contagious disease in newborn piglets and
causes substantial economic losses in the world. PED virus (PEDV) spreads by fecal–oral …

Construction and immunogenicity analysis of Lactobacillus plantarum expressing a porcine epidemic diarrhea virus S gene fused to a DC-targeting peptide

KY Huang, GL Yang, YB Jin, J Liu, HL Chen, PB Wang… - Virus research, 2018 - Elsevier
Porcine epidemic diarrhea virus (PEDV) is one of the most important causative pathogens of
swine diarrhea, which is widely prevalent throughout the world and is responsible for …

A flagellin-adjuvanted inactivated porcine epidemic diarrhea virus (PEDV) vaccine provides enhanced immune protection against PEDV challenge in piglets

X Xu, L Du, B Fan, B Sun, J Zhou, R Guo, Z Yu, D Shi… - Archives of …, 2020 - Springer
Since late 2010, outbreaks of porcine epidemic diarrhea (PED) have been reported in the
swine industry in China. A variant PEDV strain that differs from strain CV777 causes …

Efficient priming of CD4 T cells by Langerin-expressing dendritic cells targeted with porcine epidemic diarrhea virus spike protein domains in pigs

S Subramaniam, D Cao, D Tian, QM Cao, C Overend… - Virus research, 2017 - Elsevier
Porcine epidemic diarrhea virus (PEDV) first emerged in the United States in 2013 causing
high mortality and morbidity in neonatal piglets with immense economic losses to the swine …