Individuals with cystic fibrosis (CF) suffer from frequent and recurring microbial airway
infections. The Gram-negative bacterium Pseudomonas aeruginosa is one of the most …

Chronic airway infections with Pseudomonas aeruginosa determine morbidity in most
individuals with cystic fibrosis (CF). P. aeruginosa may persist for decades in CF lungs …

Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF)
airways has shown inefficient eradication of the infecting bacteria, as well as previously …

Chronic airway infections caused by Pseudomonas aeruginosa contribute to the
progression of pulmonary disease in individuals with cystic fibrosis (CF). In the setting of CF …

Pseudomonas aeruginosa populations undergo a characteristic evolutionary adaptation
during chronic infection of the cystic fibrosis (CF) lung, including reduced production of …

ABSTRACT The Gram-negative bacterium Pseudomonas aeruginosa is a common cause of
chronic airway infections in individuals with the heritable disease cystic fibrosis (CF). After …

The opportunistic pathogen Pseudomonas aeruginosa chronically infects the lower airways
of patients with cystic fibrosis. Throughout the course of infection this organism undergoes …

The ability to establish lifelong persistent infections is a fundamental aspect of the
interactions between many pathogenic microorganisms and their mammalian hosts. One …

Rationale: Pseudomonas aeruginosa, the predominant cause of chronic airway infections of
patients with cystic fibrosis, exhibits extensive phenotypic diversity among isolates within …

The evolution and diversification of bacterial pathogens within human hosts represent
potential barriers to the diagnosis and treatment of life-threatening infections. Tremendous …