The comparative genomics of the transition of the opportunistic pathogen Pseudomonas
aeruginosa from a free-living environmental strain to one that causes chronic infection in the …

The evolution and diversification of bacterial pathogens within human hosts represent
potential barriers to the diagnosis and treatment of life-threatening infections. Tremendous …

Rationale: Pseudomonas aeruginosa undergoes phenotypic changes during cystic fibrosis
(CF) lung infection. Although mucoidy is traditionally associated with transition to chronic …

Background Pseudomonas aeruginosa establishes life-long chronic airway infections in
cystic fibrosis (CF) patients. As the disease progresses, P. aeruginosa pathoadaptive …

Highlights•Pseudomonas aeruginosa in CF airways: paradigm of bacterial microevolution.•
Evolution within CF host triggers conversions of genotype and phenotype.•Severity of lung …

The opportunistic pathogen Pseudomonas aeruginosa chronically infects the lungs of
patients with cystic fibrosis (CF). During infection the bacteria evolve and adapt to the lung …

Chronic infection of the cystic fibrosis (CF) airway by the opportunistic pathogen
Pseudomonas aeruginosa is the leading cause of morbidity and mortality for adult CF …

Background: During its persistence in cystic fibrosis (CF) airways, P. aeruginosa develops a
series of phenotypic changes by the accumulation of pathoadaptive mutations. A better …

Abstract The Cystic Fibrosis (CF) lung harbors a complex, polymicrobial ecosystem, in which
Pseudomonas aeruginosa is capable of sustaining chronic infections, which are highly …

Most patients with the genetic disease cystic fibrosis (CF) succumb to chronic airway
infection caused by the bacterium Pseudomonas aeruginosa. CF lung disease follows a …