Metabolic adaptations of Pseudomonas aeruginosa during cystic fibrosis chronic lung infections

V Behrends, B Ryall, JEA Zlosnik… - Environmental …, 2013 - Wiley Online Library
Pseudomonas aeruginosa forms chronic infections in the lungs of cystic fibrosis (CF)
patients, and is the leading cause of morbidity and mortality in patients with CF …

Pseudomonas aeruginosa syntrophy in chronically colonized airways of cystic fibrosis patients

X Qin, DM Zerr, MA McNutt, JE Berry… - Antimicrobial agents …, 2012 - Am Soc Microbiol
Pseudomonas aeruginosa isolates from cystic fibrosis (CF) patients undergo remarkable
phenotypic divergence over time, including loss of pigmentation, hemolysis, motility, and …

Pseudomonas aeruginosa Microevolution during Cystic Fibrosis Lung Infection Establishes Clones with Adapted Virulence

A Bragonzi, M Paroni, A Nonis, N Cramer… - American journal of …, 2009 - atsjournals.org
Rationale: During long-term lung infection in patients with cystic fibrosis (CF), Pseudomonas
aeruginosa strains develop mutations leading to clonal expansion. This microevolution is …

[HTML][HTML] Molecular detection of an atypical, highly resistant, clonal Pseudomonas aeruginosa isolate in cystic fibrosis patients

D Keating, MJ Crowe, B Kennedy, A Salmon… - Journal of Cystic …, 2013 - Elsevier
BACKGROUND: The identification of Pseudomonas aeruginosa (P. aeruginosa) isolates in
sputum from cystic fibrosis (CF) patients can be challenging due to the multitude of …

Dynamics of Adaptive Microevolution of Hypermutable Pseudomonas aeruginosa during Chronic Pulmonary Infection in Patients with Cystic Fibrosis

C Hoboth, R Hoffmann, A Eichner… - The Journal of …, 2009 - academic.oup.com
Background. In patients with cystic fibrosis (CF), the emergence of hypermutable
Pseudomonas aeruginosa drives the selection of P. aeruginosa variants that are efficiently …

Genomic variation among contemporary Pseudomonas aeruginosa isolates from chronically infected cystic fibrosis patients

JCS Chung, J Becq, L Fraser… - Journal of …, 2012 - Am Soc Microbiol
The airways of individuals with cystic fibrosis (CF) often become chronically infected with
unique strains of the opportunistic pathogen Pseudomonas aeruginosa. Several lines of …

Selective sweeps and parallel pathoadaptation drive Pseudomonas aeruginosa evolution in the cystic fibrosis lung

J Diaz Caballero, ST Clark, B Coburn, Y Zhang… - MBio, 2015 - Am Soc Microbiol
Pulmonary infections caused by Pseudomonas aeruginosa are a recalcitrant problem in
cystic fibrosis (CF) patients. While the clinical implications and long-term evolutionary …

[HTML][HTML] Within-host microevolution of Pseudomonas aeruginosa in Italian cystic fibrosis patients

RL Marvig, D Dolce, LM Sommer, B Petersen, O Ciofu… - BMC microbiology, 2015 - Springer
Abstract Background Chronic infection with Pseudomonas aeruginosa is a major cause of
morbidity and mortality in cystic fibrosis (CF) patients, and a more complete understanding of …

Evolutionary insight from Whole-Genome Sequencing of Pseudomonas Aeruginosa from Cystic Fibrosis Patients

RL Marvig, LM Sommer, L Jelsbak, S Molin… - Future …, 2015 - Taylor & Francis
The opportunistic pathogen Pseudomonas aeruginosa causes chronic airway infections in
patients with cystic fibrosis (CF), and it is directly associated with the morbidity and mortality …

Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective

A Folkesson, L Jelsbak, L Yang, HK Johansen… - Nature Reviews …, 2012 - nature.com
The airways of patients with cystic fibrosis (CF) are nearly always infected with many
different microorganisms. This environment offers warm, humid and nutrient-rich conditions …