[HTML][HTML] High virulence sub-populations in Pseudomonas aeruginosa long-term cystic fibrosis airway infections
Background Pseudomonas aeruginosa typically displays loss of virulence-associated
secretions over the course of chronic cystic fibrosis infections. This has led to the suggestion …
secretions over the course of chronic cystic fibrosis infections. This has led to the suggestion …
Epidemiology of Clonal Pseudomonas aeruginosa Infection in a Canadian Cystic Fibrosis Population
Rationale: The extent of the genetic relatedness among Pseudomonas aeruginosa isolates
and its impact on clinical outcomes in the cystic fibrosis (CF) population is poorly …
and its impact on clinical outcomes in the cystic fibrosis (CF) population is poorly …
[HTML][HTML] Insights into the respiratory tract microbiota of patients with cystic fibrosis during early Pseudomonas aeruginosa colonization
Pseudomonas aeruginosa plays a major role in cystic fibrosis (CF) progression. Therefore, it
is important to understand the initial steps of P. aeruginosa infection. The structure and …
is important to understand the initial steps of P. aeruginosa infection. The structure and …
[HTML][HTML] Bacterial evolution in PCD and CF patients follows the same mutational steps
Infections with Pseudomonas aeruginosa increase morbidity in primary ciliary dyskinesia
(PCD) and cystic fibrosis (CF) patients. Both diseases are associated with a defect of the …
(PCD) and cystic fibrosis (CF) patients. Both diseases are associated with a defect of the …
The role of hypermutation and collateral sensitivity in antimicrobial resistance diversity of Pseudomonas aeruginosa populations in cystic fibrosis lung infection
Pseudomonas aeruginosa is an opportunistic pathogen which causes chronic, drug-
resistant lung infections in cystic fibrosis (CF) patients. In this study, we explore the role of …
resistant lung infections in cystic fibrosis (CF) patients. In this study, we explore the role of …
[HTML][HTML] Phenotypic and genotypic characteristics of Pseudomonas aeruginosa isolated from cystic fibrosis patients with chronic infections
A Iwańska, EA Trafny, M Czopowicz… - Scientific Reports, 2023 - nature.com
Patients with cystic fibrosis are predisposed to chronic respiratory tract infections caused by
Pseudomonas aeruginosa. As the disease progresses, the microorganism diversifies into …
Pseudomonas aeruginosa. As the disease progresses, the microorganism diversifies into …
Repeated isolation of an antibiotic-dependent and temperature-sensitive mutant of Pseudomonas aeruginosa from a cystic fibrosis patient
DJ Wolter, A Scott, CR Armbruster… - Journal of …, 2021 - academic.oup.com
Background Bacteria adapt to survive and grow in different environments. Genetic mutations
that promote bacterial survival under harsh conditions can also restrict growth. The causes …
that promote bacterial survival under harsh conditions can also restrict growth. The causes …
[HTML][HTML] Genotypic Diversity within a Single Pseudomonas aeruginosa Strain Commonly Shared by Australian Patients with Cystic Fibrosis
In cystic fibrosis (CF), Pseudomonas aeruginosa undergoes intra-strain genotypic and
phenotypic diversification while establishing and maintaining chronic lung infections. As the …
phenotypic diversification while establishing and maintaining chronic lung infections. As the …
Shared Pseudomonas aeruginosa genotypes are common in Australian cystic fibrosis centres
Recent molecular-typing studies suggest cross-infection as one of the potential acquisition
pathways for Pseudomonas aeruginosa in patients with cystic fibrosis (CF). In Australia …
pathways for Pseudomonas aeruginosa in patients with cystic fibrosis (CF). In Australia …
[HTML][HTML] Compensatory evolution of Pseudomonas aeruginosa's slow growth phenotype suggests mechanisms of adaptation in cystic fibrosis
Long-term infection of the airways of cystic fibrosis patients with Pseudomonas aeruginosa
is often accompanied by a reduction in bacterial growth rate. This reduction has been …
is often accompanied by a reduction in bacterial growth rate. This reduction has been …