Secondary pharmacological profiling is increasingly applied in pharmaceutical drug
discovery to address unwanted pharmacological side effects of drug candidates before …

Highlights•Secondary pharmacology has become an essential element of drug discovery,
accepted by the pharmaceutical industry and health authorities.•Reverse translation defines …

In vitro pharmacological profiling is increasingly being used earlier in the drug discovery
process to identify undesirable off-target activity profiles that could hinder or halt the …

Importance of the field: Anticipating the likely side effect profile of drugs is an aspect of key
importance in current drug discovery, development and marketing. It was recently shown …

A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Fifth
Edition features the latest ideas and research regarding the application of pharmacology to …

Identification of novel new molecules which hold the greatest promise of safe and effective
therapies remains a continuous challenge to the pharmaceutical industry. This has led the …

This overview unit describes the core activities involved in the drug discovery and
development process, from target identification‐including preclinical biology, medicinal and …

Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …

Drug development is a high cost and laborious process, requiring a number of tests until a
drug is made available in the market. Therefore, the use of methods to screen large number …

Highlights•Reactive metabolite formation has been linked to drug-induced
toxicity.•Avoidance strategy widely applied in industry at early stages of drug discovery.•In …