Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine/threonine kinase
with essential roles in cytoskeletal functions. Substantial evidence implicates ROCK as a …

Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine/threonine kinase
that was originally identified as RhoA interacting protein. A diverse array of cellular …

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease and is
strongly associated with cardiovascular mortality. Given the pandemic of obesity and …

Small GTP ases of the R ho family and their down‐stream effectors R ho associated kinases
(ROCKs) are the molecules that converge a spectrum of pathophysiological signals …

Abstract The small GTPase Rho and its effector Rho-kinase (ROCK) are activated in the
diabetic kidney, and recent studies decade have demonstrated that ROCK signaling is an …

OBJECTIVE—RhoA, a small GTPase protein, and its immediate downstream target, Rho
kinase (ROCK), control a wide variety of signal transduction pathways. Recent studies have …

Despite remaining questions in this field, such as the specificity of currently available
ROCKi, or the roles of individual ROCK isoforms, recent evidence in experimental diabetes …

Rho-associated kinases (ROCK) are activated in the kidney as well as in cultured cells of
diabetic models and have been implicated in renal pathophysiology. To explore whether …

Rho-associated, coiled-coil containing kinases (ROCK) were originally identified as effectors
of the RhoA small GTPase and found to belong to the AGC family of serine/threonine …

Diabetic kidney disease (DKD) stands as a pressing health challenge, with mesangial cell
fibrosis identified as a pivotal hallmark leading to glomerular sclerosis. Gaining a deeper …