Skeletal muscle is a tissue composed of oriented and dense myofibers. Upon injury, a repair
process, known as myogenesis, is initiated to replace damaged fibers. Impairment of this …

Debilitating cancer-induced muscle wasting, a syndrome known as cachexia, is lethal. Here
we report a posttranscriptional pathway involving the RNA-binding protein HuR as a key …

In this report, we investigate the role of the RNA-binding protein HuR during skeletal
myogenesis. At the onset of myogenesis in differentiating C2C12 myocytes and in vivo in …

The formation of muscle fibers involves the sequential expression of many proteins that
regulate key steps during myoblast-to-myotube transition. MyoD, myogenin, and the cyclin …

The master posttranscriptional regulator HuR promotes muscle fiber formation in cultured
muscle cells. However, its impact on muscle physiology and function in vivo is still unclear …

Post-transcriptional regulation of gene expression enables cells to fine-tune the expression
of a protein in a spatial and temporal manner. This regulation is mediated by the binding of …

Although the function of posttranscriptional processes in regulating the expression of genes
involved in muscle fiber formation (myogenesis) is well accepted, the mechanisms by which …

Metabolic Flexibility allows for the oxidation of fuels based on their availability. Respiratory
Quotient (RQ) values from subjects with type 2 diabetes mellitus in both basal and insulin …

HuR promotes myogenesis by stabilizing the MyoD, myogenin and p21 mRNAs during the
fusion of muscle cells to form myotubes. Here we show that HuR, via a novel mRNA …

Abstract Poly (ADP-ribosylation)(PARylation) is a post-translational modification mediated
by a subset of ADP-ribosyl transferases (ARTs). Although PARylation-inhibition based …