Peripheral nerves exist in a stable state in adulthood providing a rapid bidirectional
signaling system to control tissue structure and function. However, following injury …

How tissues are maintained over a lifetime and repaired following injury are fundamental
questions in biology with a disruption to these processes underlying pathologies such as …

The specialized role of the Schwann cell is reviewed in the context of peripheral nerve,
spanning neural development, anatomy, signaling, and function. A particular focus of this …

Peripheral nerve injuries arising from trauma or disease can lead to sensory and motor
deficits and neuropathic pain. Despite the purported ability of the peripheral nerve to self …

Peripheral nerves are highly regenerative, in contrast to the poor regenerative capabilities of
the central nervous system (CNS). Here, we show that adult peripheral nerve is a more …

The remarkable plasticity of Schwann cells allows them to adopt the Remak (non-myelin)
and myelin phenotypes, which are specialized to meet the needs of small and large …

After peripheral nerve injury, both Schwann cells and PNS neurons reprogram to new
phenotypes that promote repair. Myelin and Remak cells generate repair Schwann cells that …

The glial cell of the peripheral nervous system (PNS), the Schwann cell (SC), counts among
the most multifaceted cells of the body. During development, SCs secure neuronal survival …

Repair in the peripheral nervous system (PNS) depends upon the plasticity of the
myelinating cells, Schwann cells, and their ability to dedifferentiate, direct axonal regrowth …

Rodent models of nerve injury have increased our understanding of peripheral nerve
regeneration, but clinical applications have been scarce, partly because such models do not …