Although many observational studies have shown that peripheral nerve regeneration is
impaired with aging, underlying cellular and molecular mechanisms have remained obscure …

This chapter provides a review of immune reactions involved in classic as well as alternative
methods of peripheral nerve regeneration, and mainly with a view to understanding their …

The fundamental roles of Schwann cells during peripheral nerve formation and regeneration
have been recognized for more than 100 years, but the cellular and molecular mechanisms …

A clear need exists for new surgical approaches to enhance the recuperation of functions
after peripheral nerve injury and repair. At present, advances in the regenerative medicine …

Schwann cells exhibit a high degree of plasticity in adult peripheral nerves after mechanical
injury; they have, therefore, been implicated in promoting nerve regeneration. However …

Schwann cells show remarkable versatility in undertaking a broad repertoire of functions.
Ensheathment and myelination are specifically regulated by contact with axons, and the …

A determinant of axon regeneration is the intrinsic growth ability of injured neurons, which
dictates a battery of injury responses in axons and cell bodies. While some of these …

Traumatic nerve injuries result in devastating loss of neurologic function with unpredictable
functional recovery despite optimal medical management. After traumatic nerve injury and …

Axons share a close relationship with Schwann cells, their glial partners in peripheral
nerves. An intricate axo‐glia network of signals and bioactive molecules regulates the major …

Schwann cells (SCs) are fundamental components of the peripheral nervous system (PNS)
of all vertebrates and play essential roles in development, maintenance, function, and …