Human stem cells as targets for the aging and diseases of aging processes

JE Trosko - Medical Hypotheses, 2003 - Elsevier
While many theories have been proposed for the aging process, and many debates on the
matter of aging and the diseases of aging being either the result of the same or independent …

[HTML][HTML] Human adult stem cells as the target cells for the initiation of carcinogenesis and for the generation of “cancer stem cells”

JE Trosko - International journal of stem cells, 2008 - ncbi.nlm.nih.gov
The inference to stem cells has been found in ancient myths and the concept of stem cells
has existed in the fields of plant biology, developmental biology and embryology for …

[HTML][HTML] Aging of the inceptive cellular population: the relationship between stem cells and aging

CE Symonds, U Galderisi, A Giordano - Aging, 2009 - ncbi.nlm.nih.gov
The average life expectancy worldwide has about doubled and the global population has
increased six fold over the past century. With improving health care in the developed world …

All the adult stem cells, where do they all come from? An external source for organ-specific stem cell pools

NB Nardi - Medical hypotheses, 2005 - Elsevier
Stem cells can self-renew and maintain the ability to differentiate into mature lineages.
Whereas the “stemness” of embryonic stem cells is not discussed, the primitiveness of a …

Stem cells and aging: expanding the possibilities

MS Rao, MP Mattson - Mechanisms of ageing and development, 2001 - Elsevier
In the very early stages of embryonic development, cells have the capability of dividing
indefinately and then differentiating into any type of cell in the body. Recent studies have …

A role for stem cell biology in the physiological and pathological aspects of aging

EY Snyder, JF Loring - Journal of the American Geriatrics …, 2005 - Wiley Online Library
The stem cell is an essential component of a developmental phenomenon—one of the key
components of a program fundamental to organogenesis and the maintenance of …

[HTML][HTML] Stem cells and ageing: The potential of stem cells to overcome age‐related deteriorations of the body in regenerative medicine

AD Ho, W Wagner, U Mahlknecht - EMBO reports, 2005 - embopress.org
Ageing is a complex process that involves every cell and organ in the body and that leads to
the deterioration of many body functions over the lifespan of an individual (Clark, 1999). With …

[HTML][HTML] Adult stem cell and mesenchymal progenitor theories of aging

S Fukada, Y Ma, A Uezumi - Frontiers in cell and developmental …, 2014 - frontiersin.org
Advances in medical science and technology allow people live longer lives, which results in
age-related problems. Humans cannot avoid the various aged-related alterations of aging; …

Bone marrow stem cells, aging, and age-related diseases

N Ahamad, PC Rath - Models, molecules and mechanisms in …, 2019 - Springer
Bone marrow is a soft, gelatinous, and dynamic tissue present in the central cavity of long
bones such as the femora and humeri. Bone marrow is a large reservoir of pluripotent stem …

Stem cells and genetics in the study of development, aging, and longevity

G Van Zant - The Molecular Genetics of Aging, 2000 - Springer
Abstract Development and aging, indispensable in the case of the former and regrettably
unavoidable in that of the latter, are inextricably linked. Most fundamental to this relationship …