Heme is the reactive center of several metal-based proteins that are involved in multiple
biological processes. However, free heme, defined as the labile heme pool, has toxic …

Hemolysis is a complication in septic infections with Staphylococcus aureus, which utilizes
the released Hb as an iron source. S. aureus can acquire heme in vitro from hemoglobin …

Heme, as a hydrophobic iron-containing organic ring, is lipid soluble and can interact with
biological membranes. The very same properties of heme that nature exploits to support life …

Heme scavenging by plasma proteins, including serum albumin (SA), provides protection
against free‐heme oxidative damage, limits access by pathogens to the heme, and …

Extracellular hemoglobin, a byproduct of hemolysis, can release its prosthetic heme groups
upon oxidation. This produces metabolically active heme that is exchangeable between …

Staphylococcus aureus is a leading cause of life-threatening infections in the United States.
It actively acquires the essential nutrient iron from human hemoglobin (Hb) using the iron …

The extreme limitation of free iron has driven various pathogens to acquire iron from the host
in the form of heme. Specifically, several Gram-negative pathogens secrete a heme binding …

Staphylococcus aureus is a leading cause of life-threatening infections in the United States.
It requires iron to grow, which must be actively procured from its host to successfully mount …

Gram‐negative pathogenic bacteria have evolved novel strategies to obtain iron from host
haem‐sequestering proteins. These include the production of specific outer membrane …

Iron is an essential nutrient for all living organisms. To acquire iron, many pathogens have
developed elaborate systems to steal it from their hosts. The iron acquisition system in the …