Trivalent mRNA Vaccine against SARS-CoV-2 and Variants with Effective Immunization

J Wang, Y Zhang, C Liu, W Zha, S Dong… - Molecular …, 2023 - ACS Publications
mRNA vaccines encoding a single spike protein effectively prevent severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection. However, the emergence of SARS-CoV-2 …

Clinical development of mRNA vaccines: challenges and opportunities

A August, L Brito, R Paris, T Zaks - mRNA Vaccines, 2022 - Springer
The emergence of safe and effective mRNA platform-based COVID-19 vaccines from the
recent pandemic has changed the face of vaccine development. Compared with …

[HTML][HTML] Rational development of a combined mRNA vaccine against COVID-19 and influenza

Q Ye, M Wu, C Zhou, X Lu, B Huang, N Zhang, H Zhao… - npj Vaccines, 2022 - nature.com
As the world continues to experience the COVID-19 pandemic, seasonal influenza remain a
cause of severe morbidity and mortality globally. Worse yet, coinfection with SARS-CoV-2 …

[HTML][HTML] Non-immunotherapy application of LNP-mRNA: Maximizing efficacy and safety

I Vlatkovic - Biomedicines, 2021 - mdpi.com
Lipid nanoparticle (LNP) formulated messenger RNA-based (LNP-mRNA) vaccines came
into the spotlight as the first vaccines against SARS-CoV-2 virus to be applied worldwide …

[HTML][HTML] Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2

Z Fang, L Peng, R Filler, K Suzuki, A McNamara… - Nature …, 2022 - nature.com
The Omicron variant of SARS-CoV-2 recently swept the globe and showed high level of
immune evasion. Here, we generate an Omicron-specific lipid nanoparticle (LNP) mRNA …

[HTML][HTML] Role of drug delivery technologies in the success of COVID-19 vaccines: a perspective

HI Labouta, R Langer, PR Cullis, OM Merkel… - Drug Delivery and …, 2022 - Springer
The triumphant success of mRNA vaccines is a testimony to the important role drug delivery
technologies have played in protecting billions of people against SARS-CoV-2 (or the …

The Quest for mRNA Vaccines

E Gilboa, D Boczkowski, SK Nair - nucleic acid therapeutics, 2022 - liebertpub.com
The success of mRNA vaccines against COVID-19 is nothing short of a medical revolution.
Given its chemical lability the use of mRNA as a therapeutic has been counterintuitive and …

[HTML][HTML] Innate and Adaptive Immune Parameters following mRNA Vaccination in Mice

SR Bonam, NC Hazell, MJ Mathew, Y Liang, X Zhang… - Vaccines, 2024 - mdpi.com
The COVID-19 pandemic has raised the standard regarding the current vaccine
development pace, as several messenger RNA (mRNA)-lipid nanoparticle (LNP) vaccines …

[PDF][PDF] The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory

S Ndeupen, Z Qin, S Jacobsen, A Bouteau… - Iscience, 2021 - cell.com
Vaccines based on mRNA-containing lipid nanoparticles (LNPs) are a promising new
platform used by two leading vaccines against COVID-19. Clinical trials and ongoing …

[PDF][PDF] A thermostable mRNA vaccine against COVID-19

NN Zhang, XF Li, YQ Deng, H Zhao, YJ Huang, G Yang… - Cell, 2020 - cell.com
There is an urgent need for vaccines against coronavirus disease 2019 (COVID-19)
because of the ongoing SARS-CoV-2 pandemic. Among all approaches, a messenger RNA …