Trivalent mRNA Vaccine against SARS-CoV-2 and Variants with Effective Immunization
J Wang, Y Zhang, C Liu, W Zha, S Dong… - Molecular …, 2023 - ACS Publications
mRNA vaccines encoding a single spike protein effectively prevent severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection. However, the emergence of SARS-CoV-2 …
syndrome coronavirus 2 (SARS-CoV-2) infection. However, the emergence of SARS-CoV-2 …
Clinical development of mRNA vaccines: challenges and opportunities
A August, L Brito, R Paris, T Zaks - mRNA Vaccines, 2022 - Springer
The emergence of safe and effective mRNA platform-based COVID-19 vaccines from the
recent pandemic has changed the face of vaccine development. Compared with …
recent pandemic has changed the face of vaccine development. Compared with …
[HTML][HTML] Rational development of a combined mRNA vaccine against COVID-19 and influenza
Q Ye, M Wu, C Zhou, X Lu, B Huang, N Zhang, H Zhao… - npj Vaccines, 2022 - nature.com
As the world continues to experience the COVID-19 pandemic, seasonal influenza remain a
cause of severe morbidity and mortality globally. Worse yet, coinfection with SARS-CoV-2 …
cause of severe morbidity and mortality globally. Worse yet, coinfection with SARS-CoV-2 …
[HTML][HTML] Non-immunotherapy application of LNP-mRNA: Maximizing efficacy and safety
I Vlatkovic - Biomedicines, 2021 - mdpi.com
Lipid nanoparticle (LNP) formulated messenger RNA-based (LNP-mRNA) vaccines came
into the spotlight as the first vaccines against SARS-CoV-2 virus to be applied worldwide …
into the spotlight as the first vaccines against SARS-CoV-2 virus to be applied worldwide …
[HTML][HTML] Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2
The Omicron variant of SARS-CoV-2 recently swept the globe and showed high level of
immune evasion. Here, we generate an Omicron-specific lipid nanoparticle (LNP) mRNA …
immune evasion. Here, we generate an Omicron-specific lipid nanoparticle (LNP) mRNA …
[HTML][HTML] Role of drug delivery technologies in the success of COVID-19 vaccines: a perspective
The triumphant success of mRNA vaccines is a testimony to the important role drug delivery
technologies have played in protecting billions of people against SARS-CoV-2 (or the …
technologies have played in protecting billions of people against SARS-CoV-2 (or the …
The Quest for mRNA Vaccines
E Gilboa, D Boczkowski, SK Nair - nucleic acid therapeutics, 2022 - liebertpub.com
The success of mRNA vaccines against COVID-19 is nothing short of a medical revolution.
Given its chemical lability the use of mRNA as a therapeutic has been counterintuitive and …
Given its chemical lability the use of mRNA as a therapeutic has been counterintuitive and …
[HTML][HTML] Innate and Adaptive Immune Parameters following mRNA Vaccination in Mice
The COVID-19 pandemic has raised the standard regarding the current vaccine
development pace, as several messenger RNA (mRNA)-lipid nanoparticle (LNP) vaccines …
development pace, as several messenger RNA (mRNA)-lipid nanoparticle (LNP) vaccines …
[PDF][PDF] The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory
Vaccines based on mRNA-containing lipid nanoparticles (LNPs) are a promising new
platform used by two leading vaccines against COVID-19. Clinical trials and ongoing …
platform used by two leading vaccines against COVID-19. Clinical trials and ongoing …
[PDF][PDF] A thermostable mRNA vaccine against COVID-19
NN Zhang, XF Li, YQ Deng, H Zhao, YJ Huang, G Yang… - Cell, 2020 - cell.com
There is an urgent need for vaccines against coronavirus disease 2019 (COVID-19)
because of the ongoing SARS-CoV-2 pandemic. Among all approaches, a messenger RNA …
because of the ongoing SARS-CoV-2 pandemic. Among all approaches, a messenger RNA …