mRNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
have played a key role in reducing morbidity and mortality from coronavirus disease 2019 …

Available prophylactic vaccines help prevent many infectious diseases that burden
humanity. Future vaccinology will likely extend these benefits by more effectively countering …

Regardless of the underlying mechanisms, a pressing question for therapies in development
remains: what approaches should the field undertake to mitigate inflammation? On the …

The creation of safe and effective vaccines that induce potent cellular and humoral immune
responses against SARS-CoV-2 is urgently needed to end the global COVID-19 epidemic …

Lipid nanoparticle (LNP)-encapsulated nucleoside-modified mRNA vaccines have
demonstrated potency in multiple preclinical models against various pathogens and have …

Here, we assessed the efficacy of a lipid nanoparticle-based mRNA vaccine candidate
encoding the receptor-binding domain (LNP-mRNA-RBD) in mice. Mice immunized with …

Despite the various vaccines that have been developed to combat the coronavirus disease
2019 (COVID-19) pandemic, the persistent and unpredictable mutations of the severe acute …

Lipid nanoparticles (LNPs) are the prime delivery vehicle for mRNA vaccines. Previous
hypotheses suggested that LNPs contribute to innate reactogenicity and lead to the …

COVID-19 mRNA vaccines effectively reduce incidence of severe disease, hospitalisation
and death. The biodistribution and pharmacokinetics of the mRNA-containing lipid …

Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.
1/B. 1.1. 529) harboring up to 36 mutations in spike protein, the target of neutralizing …