FOXP Genes, Neural Development, Speech and Language Disorders
H Takahashi, K Takahashi, FC Liu - … factors: vital elements in biology and …, 2010 - Springer
Foxp subfamily genes were recently recognized to be members of the Fox gene family. Foxp
subfamily members contain a zinc finger domain and a leucine zipper motif in addition to a …
subfamily members contain a zinc finger domain and a leucine zipper motif in addition to a …
Characterization of Foxp2 and Foxp1 mRNA and protein in the developing and mature brain
RJ Ferland, TJ Cherry, PO Preware… - Journal of …, 2003 - Wiley Online Library
Foxp2 and Foxp1 are recently identified members of the Fox family of winged‐helix/forkhead
transcription factor genes. A recent study has found that mutations in human FOXP2 produce …
transcription factor genes. A recent study has found that mutations in human FOXP2 produce …
FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder
Disruption of FOXP2, a gene encoding a forkhead‐domain transcription factor, causes a
severe developmental disorder of verbal communication, involving profound articulation …
severe developmental disorder of verbal communication, involving profound articulation …
Identification and functional characterization of de novo FOXP1 variants provides novel insights into the etiology of neurodevelopmental disorder
E Sollis, SA Graham, A Vino, H Froehlich… - Human molecular …, 2016 - academic.oup.com
De novo disruptions of the neural transcription factor FOXP1 are a recently discovered, rare
cause of sporadic intellectual disability (ID). We report three new cases of FOXP1-related …
cause of sporadic intellectual disability (ID). We report three new cases of FOXP1-related …
Multiple transcription start sites for FOXP2 with varying cellular specificities
DI Schroeder, RM Myers - Gene, 2008 - Elsevier
FOXP2 is a forkhead transcription factor implicated in developmental verbal dyspraxia, a
human speech and language disorder. FOXP2 is expressed in complex patterns during …
human speech and language disorder. FOXP2 is expressed in complex patterns during …
Expression of Foxp2, a gene involved in speech and language, in the developing and adult striatum
K Takahashi, FC Liu, K Hirokawa… - Journal of …, 2003 - Wiley Online Library
Many members of the forkhead/winged helix transcriptional factors are known to be
regulators of embryogenesis. Mutations of the Fox gene family have been implicated in a …
regulators of embryogenesis. Mutations of the Fox gene family have been implicated in a …
Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain
E Spiteri, G Konopka, G Coppola, J Bomar… - The American Journal of …, 2007 - cell.com
Mutations in FOXP2, a member of the forkhead family of transcription factor genes, are the
only known cause of developmental speech and language disorders in humans. To date …
only known cause of developmental speech and language disorders in humans. To date …
Functional characterization of rare FOXP2 variants in neurodevelopmental disorder
SB Estruch, SA Graham, SM Chinnappa… - Journal of …, 2016 - Springer
Background Heterozygous disruption of FOXP2 causes a rare form of speech and language
impairment. Screens of the FOXP2 sequence in individuals with speech/language-related …
impairment. Screens of the FOXP2 sequence in individuals with speech/language-related …
FOXP transcription factors in vertebrate brain development, function, and disorders
M Co, AG Anderson, G Konopka - Wiley Interdisciplinary …, 2020 - Wiley Online Library
FOXP transcription factors are an evolutionarily ancient protein subfamily coordinating the
development of several organ systems in the vertebrate body. Association of their genes …
development of several organ systems in the vertebrate body. Association of their genes …
Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits
KD MacDermot, E Bonora, N Sykes, AM Coupe… - The American Journal of …, 2005 - cell.com
FOXP2, the first gene to have been implicated in a developmental communication disorder,
offers a unique entry point into neuromolecular mechanisms influencing human speech and …
offers a unique entry point into neuromolecular mechanisms influencing human speech and …
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