New tumor suppressor gene captured
J Travis - Science, 1993 - science.org
Step by step, base pair by base pair, researchers have finally closed in on the gene that
causes von Hippel-Lindau (VHL) disease, a rare but deadly condition that predisposes …
causes von Hippel-Lindau (VHL) disease, a rare but deadly condition that predisposes …
[引用][C] Germline mutations detected in the von Hippel‐Lindau disease tumor suppressor gene by southern blot and direct genomic DNA sequencing
C Li, G Weber, P Ekman, J Lagercrantz… - Human …, 1998 - Wiley Online Library
INTRODUCTION von Hippel-Lindau disease (VHL) is an autosoma1 dominantly inherited
cancer syndrome with an incidence of 1 in 36,000 (Melmon and Rosen, 1964; Maher et al …
cancer syndrome with an incidence of 1 in 36,000 (Melmon and Rosen, 1964; Maher et al …
Comparative sequence analysis of the VHL tumor suppressor gene
Comparative genome analysis may provide novel insights into gene evolution and function.
To investigate the von Hippel–Lindau (VHL) disease tumor suppressor gene, we sequenced …
To investigate the von Hippel–Lindau (VHL) disease tumor suppressor gene, we sequenced …
In vitro and In vivo Models Analyzing von Hippel-Lindau Disease-Specific Mutations
WK Rathmell, MM Hickey, NA Bezman, CA Chmielecki… - Cancer research, 2004 - AACR
Mutations in the von Hippel-Lindau (VHL) tumor suppressor gene cause tissue-specific
tumors, with a striking genotype-phenotype correlation. Loss of VHL expression predisposes …
tumors, with a striking genotype-phenotype correlation. Loss of VHL expression predisposes …
The von Hippel-Lindau tumor suppressor gene: a rare and intriguing disease opening new insight into basic mechanisms of carcinogenesis
HJH Decker, EJ Weidt, J Brieger - Cancer genetics and cytogenetics, 1997 - Elsevier
The von Hippel-Lindau (VHL) disease is an inherited tumor susceptibility syndrome
featuring a high variety of benign and malignant tumors. The gene has been localized and …
featuring a high variety of benign and malignant tumors. The gene has been localized and …
[引用][C] A novel donor splice site mutation associated with two mRNAs in von Hippel—Lindau disease
T Kishida, M Yao, F Chen, ML Orcutt… - Human molecular …, 1994 - academic.oup.com
Von Hippel-Lindau disease (VHL) is an autosomal, dominantly inherited disorder
characterized by the development of retinal angiomas, central nervous system …
characterized by the development of retinal angiomas, central nervous system …
[HTML][HTML] Von Hippel-Lindau: implications in development and disease—response
KR Cargill, S Sims-Lucas - Annals of Translational Medicine, 2020 - ncbi.nlm.nih.gov
The commentary provides an excellent overview of the VHL/HIF axis and its role in cellular
oxygen sensing. The editorial authors correctly imply that our study revealed a novel role for …
oxygen sensing. The editorial authors correctly imply that our study revealed a novel role for …
Cloning and characterization of a mouse gene with homology to the human von Hippel-Lindau disease tumor suppressor gene: implications for the potential …
J Gao, JG Naglich, J Laidlaw, JM Whaley, BR Seizinger… - Cancer research, 1995 - AACR
Abstract The human von Hippel-Lindau disease (VHL) gene has recently been identified
and, based on the nucleotide sequence of a partial cDNA clone, has been predicted to …
and, based on the nucleotide sequence of a partial cDNA clone, has been predicted to …
Improved detection of germline mutations in the von Hippel‐Lindau disease tumor suppressor gene
C Stolle, G Glenn, B Zbar, JS Humphrey… - Human …, 1998 - Wiley Online Library
Abstract von Hippel‐Lindau disease (VHL) is an inherited neoplastic disorder characterized
by the development of tumors in the eyes, brain, spinal cord, inner ear, adrenal gland …
by the development of tumors in the eyes, brain, spinal cord, inner ear, adrenal gland …