Cochlear synaptopathy is the noise-induced or age-related loss of ribbon synapses between
inner hair cells (IHCs) and auditory-nerve fibers (ANFs), first reported in CBA/CaJ mice …

In animal models, exposure to high noise levels can cause permanent damage to hair-cell
synapses (cochlear synaptopathy) for high-threshold auditory nerve fibers without affecting …

After acoustic overexposure, many auditory-nerve fiber (ANF) synapses permanently retract
from surviving cochlear hair cells. This synaptopathy is hard to diagnose, since it does not …

Afferent innervation of the cochlea by the auditory nerve declines during aging and
potentially after sound overexposure, producing the common pathology known as cochlear …

Animal studies suggest that cochlear nerve degeneration precedes sensory cell
degeneration in both noise-induced hearing loss (NIHL) and age-related hearing loss …

The classic view of sensorineural hearing loss (SNHL) is that the “primary” targets are hair
cells, and that cochlear-nerve loss is “secondary” to hair cell degeneration. Our work in …

Overexposure to intense sound can cause temporary or permanent hearing loss.
Postexposure recovery of threshold sensitivity has been assumed to indicate reversal of …

In CBA/CaJ mice, confocal analysis has shown that acoustic overexposure can immediately
destroy synapses between auditory-nerve fibers (ANFs) and their peripheral targets, the …

Cochlear neuropathy resulting from unsafe noise exposure is a life altering condition that
affects many people. This hearing dysfunction follows a conserved mechanism where inner …

Objectives: Recent animal studies demonstrated that cochlear synaptopathy, a partial loss of
inner hair cell-auditory nerve fiber synapses, can occur in response to noise exposure …