Objective: Alcohol use disorders are common conditions that have enormous social and
economic consequences. Genome-wide association analyses were performed to identify …

Background Despite the high heritability of alcohol dependence (AD), the genes found to be
associated with it account for only a small proportion of its total variability. The goal of this …

Genome-wide association studies (GWAS) have revealed many single nucleotide
polymorphisms (SNPs) associated with complex traits. Although these studies frequently fail …

BACKGROUND: Given moderately strong genetic contributions to variation in alcoholism
and heaviness of drinking (50% to 60% heritability) with high correlation of genetic …

Genome-wide association studies (GWAS) currently represent the most systematic approach
to genetic research into complex disorders. They can detect associations of common …

We have used a translational Convergent Functional Genomics (CFG) approach to discover
genes involved in alcoholism, by gene-level integration of genome-wide association study …

Abstract Background/Aims: Alcohol dependence is a common severe psychiatric disorder
with a multifactorial etiology. Since the completion of the human genome project and with …

Meta-analyses of genome-wide association study data have begun to lead to promising new
discoveries for behavioral and psychiatrically relevant phenotypes (eg, schizophrenia …

Background We conducted a genomewide association study (GWAS) for maximum number
of alcoholic drinks consumed in a 24‐hour period (“MaxDrinks”), in 2 independent samples …

It is believed that multiple genetic variants with small individual effects contribute to the risk
of alcohol dependence. Such polygenic effects are difficult to detect in genome-wide …