Sepsis is one of the most common causes of death among hospitalized patients. Activity of
xanthine oxidase (XO), a reactive oxygen species-producing enzyme, is known to be …

Aim Liver plays a crucial role in innate immunity reactions. This role predisposes the liver to
innate-mediated liver injury when uncontrolled inflammation occurs. In this study, the effect …

Background Xanthine oxidase has been implicated in the pathogenesis of a wide spectrum
of diseases, and is thought to be the most important source of oxygen-free radicals and cell …

Febuxostat is a novel selective inhibitor of xanthine oxidase (XO), approved for treating
hyperuricemia. XO inhibits the generation of uric acid (UA) as well as the resulting …

Background: The aim of this study was to elucidate a possible source of oxidant stress in
experimental sepsis. Methods: For this aim, 32 Sprague-Dawley type rats were used in the …

Aims Sepsis is a severe inflammatory response to infection with an incidence rate exceeding
48 million cases and 11 million sepsis-related deaths yearly. Furthermore, sepsis remains …

Excessive acetaminophen (APAP) application is a major cause of drug-induced liver injury
(DILI). Febuxostat (Feb), a drug for reducing uric acid (UA) levels, was demonstrated to …

Xanthine oxidase activation occurs in sepsis and results in the generation of uric acid (UrAc)
and reactive oxygen species (ROS). We aimed to evaluate the effect of xanthine oxidase …

Aim Sepsis is a serious inflammatory response to infection with an annual incidence rate of>
48 million cases and 11 million fatalities worldwide. Furthermore, sepsis remains the world's …

Present investigation evaluates the protective effect of vanillin against sepsis. Sepsis was
induced by cecal ligation and puncture (CLP) in rat and vanillin was administered at dose of …