Objective. To investigate the relationship between pain-related behavior and the expression
of neurotrophic factors in the dorsal root ganglion (DRG) and spinal cord (SC) using a …

Nerve growth factor (NGF), an essential peptide for sensory neurons, seems to have
opposite effects when administered peripherally or directly to the central nervous system …

Study Design. Biochemical and immunohistochemical analyses by the human intervertebral
disc (IVD) cells and tissues. Objective. To examine the expression of glial cell line-derived …

Glial cell line-derived neurotrophic factor (GDNF), a survival-promoting factor for a subset of
nociceptive small-diameter neurons, has been shown to exert analgesic effects on …

Growth factors such as nerve growth factor and glial cell line-derived neurotrophic factor are
known to induce pain sensitization. However, a plethora of other growth factors is released …

Glial fibrillary acidic protein (GFAP) is a specific astrocytic marker in the central nervous
system. Few studies on the effects of glial cell line-derived neurotrophic factor (GDNF) …

It is generally believed that the development of neuropathic pain primarily results from
injuries to sensory afferent fibers. Recent studies found that injuries to the motor efferent …

Glial cell line-derived neurotrophic factor (GDNF) is involved in inflammation and pain, roles
which remain to be delineated clinically. We aimed to evaluate the role of central nervous …

Previous our report indicated that acute application of glial cell line-derived neurotrophic
factor (GDNF) enhances the neuronal excitability of adult rat small-diameter trigeminal …

Even in present day pain therapy, neuropathic pain remains a challenge for clinicians to
treat and a challenge for researchers to investigate. Different animal models have been …