The precursor of brain derived neurotrophic factor (proBDNF), the unprocessed BDNF gene
product, binds to its receptors and exerts the opposing biologic functions of mature BDNF …

The aim of the current study was to investigate whether, and if so how, brain‐derived
neurotrophic factor (BDNF) acts to develop the spinal sensitization underlying inflammation …

Selective motor nerve injury by lumbar 5 ventral root transection (L5 VRT) induces
neuropathic pain, but the underlying mechanisms remain unknown. Previously, increased …

Many studies support the pro-nociceptive role of brain-derived neurotrophin factor (BDNF) in
pain processes in the peripheral and central nervous system. We have previously shown …

Metastatic bone cancer causes severe pain, but current treatments often provide insufficient
pain relief. One of the reasons is that mechanisms underlying bone cancer pain are not …

Brain-derived neurotrophic factor (BDNF) is involved in neuronal survival and synaptic
plasticity of the central and peripheral nervous system. In chronic pain, plastic changes in …

Nerve growth factor (NGF) regulates sensory neuron phenotype by elevated expression of
ion channels and receptors contributing to pain. Peripheral opioid antinociception is …

Microvascular compression on the trigeminal root entry zone (TREZ) is the main etiology of
trigeminal neuralgia (TN) patients. To investigate brain‐derived neurotrophic factor (BDNF) …

Background. Glial cells are implicated in the development of chronic pain and brain‐derived
neurotropic factor (BDNF) released from activated microglia contributes to the nociceptive …

Since neuropathic pain is resistant to conventional analgesics such as opiates and non-
steroidal anti-inflammatory drugs, the development of new types of drugs for its treatment …