The non-ribosomal peptide gliotoxin, which autoinduces its own biosynthesis, has potent
anti-fungal activity, especially in the combined absence of the gliotoxin oxidoreductase GliT …

Cryptic links between apparently unrelated metabolic systems represent potential new drug
targets in fungi. Evidence of such a link between zinc and gliotoxin (GT) biosynthesis in …

Gliotoxin (GT) biosynthesis in fungi is encoded by the gli biosynthetic gene cluster. While GT
addition autoinduces biosynthesis, Zn 2+ has been shown to attenuate cluster activity, and it …

Gliotoxin is an epipolythiodioxopiperazine (ETP) class toxin, contains a disulfide bridge that
mediates its toxic effects via redox cycling and is produced by the opportunistic fungal …

Gliotoxin is a redox-active nonribosomal peptide produced by Aspergillus fumigatus. Like
many other disulfide-containing epipolythiodioxopiperazines, a bis-thiomethylated form is …

Gliotoxin is an epipolythiodioxopiperazine (ETP) class toxin, contains a disulfide bridge that
mediates its toxic effects via redox cycling and is produced by the opportunistic fungal …

The formation of glutathione (GSH) conjugates, best known from the detoxification of
xenobiotics, is a widespread strategy to incorporate sulfur into biomolecules. The …

Gliotoxin (1), the infamous representative of the group of epipolythiodioxopiperazines
(ETPs), is a virulence factor of the human pathogenic fungus Aspergillus fumigatus. The …

Gliotoxin (GT) is the prototype of the epidithiodioxopiperazine (ETP)-type fungal toxins. GT
plays a critical role in the pathobiology of Aspergillus fumigatus. It modulates the immune …

Mechanistic studies on gliotoxin biosynthesis and self-protection in Aspergillus fumigatus,
both of which require the gliotoxin oxidoreductase GliT, have revealed a rich landscape of …