Messenger RNA vaccines lack specificity for dendritic cells (DCs)—the most effective cells at
antigen presentation. Here we report the design and performance of a DC-targeting virus …

Improved vaccination requires better delivery of antigens and activation of the natural
immune response. Here we report a lipid nanoparticle system with the capacity to carry …

Spleen and lymphoid organs are important targets for messenger RNA (mRNA) delivery in
various applications. Current nanoparticle delivery methods rely on drainage to lymph …

To elicit optimal immune responses, messenger RNA vaccines require intracellular delivery
of the mRNA and the careful use of adjuvants. Here we report a multiply adjuvanted mRNA …

Infectious diseases are a leading cause of death worldwide, and vaccines are the cheapest
and efficient approach to preventing diseases. Use of conventional vaccination strategies …

Lipid nanoparticle (LNP)-mediated delivery of messenger RNA (mRNA) COVID-19 vaccines
has provided large-scale immune protection to the public. To elicit a robust immune …

Vaccines have played a fundamental role in the control of infectious diseases. We
previously developed a messenger RNA (mRNA) vaccine against HIV-1 that forms virus-like …

Recent development of SARS-CoV-2 spike mRNA vaccines to control the pandemic is a
breakthrough in the field of vaccine development. mRNA vaccines are generally formulated …

mRNA and lipid nanoparticles have emerged as powerful systems for the preparation of
vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection …

SARS-CoV-2 infection has emerged as a serious global pandemic. Because of the high
transmissibility of the virus and the high rate of morbidity and mortality associated with …