Aim: To evaluate whether SNPs (n= 15) in ten candidate genes (ADRB2, ADH5, ARGI,
CRHR1, STIP1, LTA4H, LTC4S, ALOX5, ABCC1 and OATP2B1) are associated with asthma …

Background Single‐nucleotide polymorphisms (SNPs) in the human β2 adrenergic receptor
(ADRB2) gene have been linked to pathogenesis of and treatment responses in asthma. In …

Objective: Genetic background and environmental stimuli play an important role in asthma,
which is an individual's hyper-responsiveness to these stimuli leading to airway …

Aspirin exacerbated respiratory disease (AERD) is a set of diseases of the unified airway,
and its physiopathology is related to disruption of the metabolism of arachidonic acid (AA) …

Background β2 adrenergic receptor (ADRβ2) polymorphisms including ADRβ2+ 46G> A
have been reported to cause adverse outcomes in mild asthmatics. The extent to which …

Rationale: The use of gene expression microarrays has changed the investigation of
biological processes by enabling genome-wide measurements of transcriptional activity …

Background Asthma is a phenotypically diverse disease with genetic susceptibility. A single
nucleotide polymorphism (SNP) in the CD14 gene at position-260 (also known as-159) C> T …

Background Two common clinical syndromes of acetylsalicylic acid (aspirin)
hypersensitivity, aspirin-exacerbated respiratory disease (AERD) and aspirin-exacerbated …

The pathophysiologic mechanism of allergic asthma and rhinosinusitis is so complicated
and involves thousands of inflammatory mediators. They are world-wide health problems …

Background Genetic polymorphisms may be responsible for the wide variation in response
to inhaled corticosteroids in asthmatic patients. We had previously reported that one …