Asthma exacerbations are among the most frequent causes of hospitalization during
childhood, but the underlying mechanisms are poorly understood. We performed a genome …

Background Disturbance of mucociliary clearance is an important factor in the pathogenesis
of asthma. We hypothesized that common variants in genes responsible for ciliary function …

1 ABSTRACT 2 Background: The polymorphism Arg16 in β2-adrenergic receptor (ADRB2)
gene has been 3 associated with an increased risk of exacerbations in asthmatic children …

Rationale and Objective Autophagy is a cellular process directed at eliminating or recycling
cellular proteins. Recently, the autophagy pathway has been implicated in immune …

The angiotensinogen (AGT) gene enhances the effect of several bronchoconstrictors and
produces a peptide that is accumulated in the airways of asthma patients; events that may …

Aspirin-intolerant asthma (AIA) is a rare condition that is characterized by the development
of bronchoconstriction in asthmatic patients after ingestion of non-steroidal anti-inflammatory …

Background Genetic variations in different loci and genes are important in asthma
pathogenesis. There is much importance of various immunological pathways in the IgE …

Objective: Genome-wide association studies (GWASs) have identified genes associated
with asthma, however expression of these genes in asthma-relevant tissues has not been …

Background Asthma is a disease of varying severity and differing disease mechanisms. To
date, studies aimed at stratifying asthma into clinically useful phenotypes have produced a …

To the Editor: Recently, Fricker et al 1 reported that an expression signature in the sputum
efficiently predicted exacerbations among patients with asthma, showing the greatest …