RATIONALE: Airway hyperresponsiveness (AHR) to inhaled stimulants is a key feature of
asthma. AHR has a strong genetic component; however, the genetic architecture of AHR is …

The loss of response to pharmacological treatments has always been listed among factors
that contribute to the development of severe asthma, likely because of the reduced …

Nonetheless, the pediatric pharmaco genomics field was stirred up this year with the
publication of the results of a small RCT in which children were randomized to a treatment …

Abstract LPS-ligation to CD14/TLR-4 on monocytes/macrophages triggers the production of
IL-12-family cytokines. IL12/18 promote TH1-differentiation, counteracting the TH2-driven …

Background: Asthma is a heterogeneous disease with a large variation of phenotypes. Late-
onset asthma is often characterized by non-atopic, more severe and a faster decline in lung …

Asthma is a complex disease physiologically characterized by shortness of breath,
coughing, and wheezing (Holgate, 2011). In response to a variety of stimuli, the airways …

Background. The discoidin domain receptor tyrosine kinase 1 (DDR1) is positioned within
the major histocompatibility complex (MHC) region which plays an important role in the …

Adenylyl cyclase (AC) mediates signalling following activation of G αs-coupled receptors
such as the β 2-adrenergic receptor (β 2 AR). Genetic variation in the receptor component of …

Aspirin-exacerbated respiratory disease (AERD) is a respiratory disease characterized by
acute bronchial responses upon the administration of non-steroidal anti‑inflammatory drugs …

3. Subramanian H, Gupta K, Lee D, Bayir AK, Ahn H, Ali H. Beta-defensins activate human
mast cells via Mas-related gene X2. J Immunol 2013; 191: 345-52. 4. Rohrl J, Yang D …