METTL3-mediated m6A modification of STEAP2 mRNA inhibits papillary thyroid cancer progress by blocking the Hedgehog signaling pathway and epithelial-to …

Y Zhu, X Peng, Q Zhou, L Tan, C Zhang, S Lin… - Cell death & …, 2022 - nature.com
Papillary thyroid cancer (PTC) is a common endocrine system malignancy all over the world.
Aberrant expression of six transmembrane epithelial antigen of the prostate 2 (STEAP2) has …

FTO prevents thyroid cancer progression by SLC7A11 m6A methylation in a ferroptosis-dependent manner

FH Ji, XH Fu, GQ Li, Q He, XG Qiu - Frontiers in Endocrinology, 2022 - frontiersin.org
N6 methyladenosine (m6A) modification serves as a novel epigenetic regulatory mechanism
that is heavily implicated in the heredity of tumors. Meanwhile, fat mass and obesity …

METTL3 restrains papillary thyroid cancer progression via m6A/c-Rel/IL-8-mediated neutrophil infiltration

J He, M Zhou, J Yin, J Wan, J Chu, J Jia, J Sheng… - Molecular Therapy, 2021 - cell.com
Growing evidence indicates that N6-methyladenosine (m 6 A) is the most pervasive RNA
modification in eukaryotic cells. However, the specific role of METTL3 in papillary thyroid …

METTL14 promotes prostate tumorigenesis by inhibiting THBS1 via an m6A-YTHDF2-dependent mechanism

Y Wang, J Chen, WQ Gao, R Yang - Cell death discovery, 2022 - nature.com
Abstract N6-methyladenine (m6A) is the most predominant RNA modification, which has
been shown to be related to many types of cancers. However, understanding of its role in …

METTL14 promotes tumorigenesis by regulating lncRNA OIP5-AS1/miR-98/ADAMTS8 signaling in papillary thyroid cancer

X Zhang, D Li, C Jia, H Cai, Z Lv, B Wu - Cell death & disease, 2021 - nature.com
Background Papillary thyroid cancer (PTC) is the most common type of cancer of the
endocrine system. Long noncoding RNAs (lncRNAs) are emerging as a novel class of gene …

Progression of Thyroid Carcinoma Is Promoted by the m6A Methyltransferase METTL3 Through Regulating m6A Methylation on TCF1

K Wang, L Jiang, Y Zhang, C Chen - OncoTargets and therapy, 2020 - Taylor & Francis
Objective This study aims to uncover the progression of thyroid carcinoma influenced by the
m6A methyltransferase METTL3 through regulating m6A methylation on TCF1 mRNA and …

LDHA induces EMT gene transcription and regulates autophagy to promote the metastasis and tumorigenesis of papillary thyroid carcinoma

X Hou, X Shi, W Zhang, D Li, L Hu, J Yang, J Zhao… - Cell death & …, 2021 - nature.com
Papillary thyroid carcinoma (PTC) is one of the most common kinds of endocrine-related
cancer and has a heterogeneous prognosis. Metabolic reprogramming is one of the …

Knockdown of STEAP1 inhibits cell growth and induces apoptosis in LNCaP prostate cancer cells counteracting the effect of androgens

IM Gomes, SM Rocha, C Gaspar, MI Alvelos… - Medical Oncology, 2018 - Springer
Six transmembrane epithelial antigen of the prostate 1 (STEAP1) is overexpressed in
numerous types of tumors, especially in prostate cancer. STEAP1 is located in the plasma …

STEAP3 promotes cancer cell proliferation by facilitating nuclear trafficking of EGFR to enhance RAC1-ERK-STAT3 signaling in hepatocellular carcinoma

LL Wang, J Luo, ZH He, YQ Liu, HG Li, D Xie… - Cell Death & …, 2021 - nature.com
STEAP3 (Six-transmembrane epithelial antigen of the prostate 3, TSAP6, dudulin-2) has
been reported to be involved in tumor progression in human malignancies. Nevertheless …

RNA m6A Methyltransferase METTL3 Promotes The Growth Of Prostate Cancer By Regulating Hedgehog Pathway

J Cai, F Yang, H Zhan, J Situ, W Li, Y Mao… - OncoTargets and …, 2019 - Taylor & Francis
Purpose N6-methyladenosine (m6A) is the most abundant internal modification on
eukaryotic mRNA and gained increasing attention recently. More and more evidence …