Ghrelin infused into the dorsomedial hypothalamus of male mice increases food intake and adiposity.

L Hyland, SB Park, Y Abdelaziz, A Abizaid - Physiology & behavior, 2020 - Elsevier
Ghrelin is a 28 amino acid peptide hormone that targets the brain to promote feeding and
adiposity. The ghrelin receptor, the GHSR1a, is expressed within most hypothalamic nuclei …

Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers

CB Lawrence, AC Snape, FMH Baudoin… - …, 2002 - academic.oup.com
Ghrelin was recently identified as the endogenous ligand for the GH secretagogue (GHS)
receptor. Like the synthetic GHSs [eg GH-releasing peptide-6 (GHRP-6)], ghrelin stimulates …

Acyl ghrelin acts in the brain to control liver function and peripheral glucose homeostasis in male mice

R Stark, A Reichenbach, SH Lockie, C Pracht… - …, 2015 - academic.oup.com
Recent evidence suggests that peripheral ghrelin regulates glucose metabolism. Here, we
designed experiments to examine how central acyl ghrelin infusion affects peripheral …

On the Central Mechanism Underlying Ghrelin's Chronic Pro‐Obesity Effects in Rats: New Insights from Studies Exploiting a Potent Ghrelin Receptor Antagonist

N Salomé, C Hansson, M Taube… - Journal of …, 2009 - Wiley Online Library
In the present study, we explore the central nervous system mechanism underlying the
chronic central effects of ghrelin with respect to increasing body weight and body fat …

Ghrelin stimulates GH but not food intake in arcuate nucleus ablated rats

H Tamura, J Kamegai, T Shimizu, S Ishii… - …, 2002 - academic.oup.com
Ghrelin, an endogenous ligand for the GH secretagogue receptor 1a (GHS-R1a), was
originally purified from the rat stomach. Ghrelin mRNA and peptide have also been detected …

Mice lacking ghrelin receptors resist the development of diet-induced obesity

JM Zigman, Y Nakano, R Coppari… - The Journal of …, 2005 - Am Soc Clin Investig
Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor (GHSR;
ghrelin receptor). Since its discovery, accumulating evidence has suggested that ghrelin …

Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure

PT Pfluger, H Kirchner, S Gunnel… - American Journal …, 2008 - journals.physiology.org
Administration of chemically synthesized ghrelin (Ghr) peptide has been shown to increase
food intake and body adiposity in most species. However, the biological role of endogenous …

Motivation to obtain preferred foods is enhanced by ghrelin in the ventral tegmental area

SJ King, AM Isaacs, E O'Farrell, A Abizaid - Hormones and behavior, 2011 - Elsevier
Ghrelin is an orexigenic peptide that acts within the central nervous system to stimulate
appetite and food intake via the growth hormone secretagogue receptor (GHS-R). It has …

Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference

KE Wortley, KD Anderson, K Garcia… - Proceedings of the …, 2004 - National Acad Sciences
Ghrelin is a recently identified growth hormone (GH) secretogogue whose administration not
only induces GH release but also stimulates food intake, increases adiposity, and reduces …

Hindbrain ghrelin receptor signaling is sufficient to maintain fasting glucose

MM Scott, M Perello, JC Chuang, I Sakata, L Gautron… - 2012 - journals.plos.org
The neuronal coordination of metabolic homeostasis requires the integration of hormonal
signals with multiple interrelated central neuronal circuits to produce appropriate levels of …