Ghrelin infused into the dorsomedial hypothalamus of male mice increases food intake and adiposity.
Ghrelin is a 28 amino acid peptide hormone that targets the brain to promote feeding and
adiposity. The ghrelin receptor, the GHSR1a, is expressed within most hypothalamic nuclei …
adiposity. The ghrelin receptor, the GHSR1a, is expressed within most hypothalamic nuclei …
Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers
CB Lawrence, AC Snape, FMH Baudoin… - …, 2002 - academic.oup.com
Ghrelin was recently identified as the endogenous ligand for the GH secretagogue (GHS)
receptor. Like the synthetic GHSs [eg GH-releasing peptide-6 (GHRP-6)], ghrelin stimulates …
receptor. Like the synthetic GHSs [eg GH-releasing peptide-6 (GHRP-6)], ghrelin stimulates …
Acyl ghrelin acts in the brain to control liver function and peripheral glucose homeostasis in male mice
Recent evidence suggests that peripheral ghrelin regulates glucose metabolism. Here, we
designed experiments to examine how central acyl ghrelin infusion affects peripheral …
designed experiments to examine how central acyl ghrelin infusion affects peripheral …
On the Central Mechanism Underlying Ghrelin's Chronic Pro‐Obesity Effects in Rats: New Insights from Studies Exploiting a Potent Ghrelin Receptor Antagonist
N Salomé, C Hansson, M Taube… - Journal of …, 2009 - Wiley Online Library
In the present study, we explore the central nervous system mechanism underlying the
chronic central effects of ghrelin with respect to increasing body weight and body fat …
chronic central effects of ghrelin with respect to increasing body weight and body fat …
Ghrelin stimulates GH but not food intake in arcuate nucleus ablated rats
H Tamura, J Kamegai, T Shimizu, S Ishii… - …, 2002 - academic.oup.com
Ghrelin, an endogenous ligand for the GH secretagogue receptor 1a (GHS-R1a), was
originally purified from the rat stomach. Ghrelin mRNA and peptide have also been detected …
originally purified from the rat stomach. Ghrelin mRNA and peptide have also been detected …
Mice lacking ghrelin receptors resist the development of diet-induced obesity
Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor (GHSR;
ghrelin receptor). Since its discovery, accumulating evidence has suggested that ghrelin …
ghrelin receptor). Since its discovery, accumulating evidence has suggested that ghrelin …
Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure
PT Pfluger, H Kirchner, S Gunnel… - American Journal …, 2008 - journals.physiology.org
Administration of chemically synthesized ghrelin (Ghr) peptide has been shown to increase
food intake and body adiposity in most species. However, the biological role of endogenous …
food intake and body adiposity in most species. However, the biological role of endogenous …
Motivation to obtain preferred foods is enhanced by ghrelin in the ventral tegmental area
Ghrelin is an orexigenic peptide that acts within the central nervous system to stimulate
appetite and food intake via the growth hormone secretagogue receptor (GHS-R). It has …
appetite and food intake via the growth hormone secretagogue receptor (GHS-R). It has …
Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference
KE Wortley, KD Anderson, K Garcia… - Proceedings of the …, 2004 - National Acad Sciences
Ghrelin is a recently identified growth hormone (GH) secretogogue whose administration not
only induces GH release but also stimulates food intake, increases adiposity, and reduces …
only induces GH release but also stimulates food intake, increases adiposity, and reduces …
Hindbrain ghrelin receptor signaling is sufficient to maintain fasting glucose
The neuronal coordination of metabolic homeostasis requires the integration of hormonal
signals with multiple interrelated central neuronal circuits to produce appropriate levels of …
signals with multiple interrelated central neuronal circuits to produce appropriate levels of …