Divergent, Coexisting Pseudomonas aeruginosa Lineages in Chronic Cystic Fibrosis Lung Infections

D Williams, B Evans, S Haldenby… - American journal of …, 2015 - atsjournals.org
Rationale: Pseudomonas aeruginosa, the predominant cause of chronic airway infections of
patients with cystic fibrosis, exhibits extensive phenotypic diversity among isolates within …

Pseudomonas aeruginosa Population Diversity and Turnover in Cystic Fibrosis Chronic Infections

E Mowat, S Paterson, JL Fothergill… - American journal of …, 2011 - atsjournals.org
Rationale: Pseudomonas aeruginosa isolates from chronic cystic fibrosis lung infections
display multiple phenotypes indicating extensive population diversity. Objectives: We aimed …

Genomic variation among contemporary Pseudomonas aeruginosa isolates from chronically infected cystic fibrosis patients

JCS Chung, J Becq, L Fraser… - Journal of …, 2012 - Am Soc Microbiol
The airways of individuals with cystic fibrosis (CF) often become chronically infected with
unique strains of the opportunistic pathogen Pseudomonas aeruginosa. Several lines of …

Long-Term Microevolution of Pseudomonas aeruginosa Differs between Mildly and Severely Affected Cystic Fibrosis Lungs

J Klockgether, N Cramer, S Fischer… - American journal of …, 2018 - atsjournals.org
Chronic airway infections with Pseudomonas aeruginosa determine morbidity in most
individuals with cystic fibrosis (CF). P. aeruginosa may persist for decades in CF lungs …

Evolutionary genomics of epidemic and nonepidemic strains of Pseudomonas aeruginosa

JR Dettman, N Rodrigue, SD Aaron… - Proceedings of the …, 2013 - National Acad Sciences
Pseudomonas aeruginosa is an opportunistic pathogen of humans and is a major cause of
morbidity and mortality in patients with cystic fibrosis (CF). Prolonged infection of the …

Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis

E Rossi, R La Rosa, JA Bartell, RL Marvig… - Nature Reviews …, 2021 - nature.com
Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF)
airways has shown inefficient eradication of the infecting bacteria, as well as previously …

Evolutionary Genomics of Niche-Specific Adaptation to the Cystic Fibrosis Lung in Pseudomonas aeruginosa

JR Dettman, R Kassen - Molecular biology and evolution, 2021 - academic.oup.com
The comparative genomics of the transition of the opportunistic pathogen Pseudomonas
aeruginosa from a free-living environmental strain to one that causes chronic infection in the …

[HTML][HTML] Pseudomonas aeruginosa evolutionary adaptation and diversification in cystic fibrosis chronic lung infections

C Winstanley, S O'Brien, MA Brockhurst - Trends in microbiology, 2016 - cell.com
Pseudomonas aeruginosa populations undergo a characteristic evolutionary adaptation
during chronic infection of the cystic fibrosis (CF) lung, including reduced production of …

[HTML][HTML] Genome evolution drives transcriptomic and phenotypic adaptation in Pseudomonas aeruginosa during 20 years of infection

SJT Wardell, J Gauthier, LW Martin… - Microbial …, 2021 - microbiologyresearch.org
The opportunistic pathogen Pseudomonas aeruginosa chronically infects the lungs of
patients with cystic fibrosis (CF). During infection the bacteria evolve and adapt to the lung …

[HTML][HTML] Phenotypic Heterogeneity of Pseudomonas aeruginosa Populations in a Cystic Fibrosis Patient

ML Workentine, CD Sibley, B Glezerson, S Purighalla… - PloS one, 2013 - journals.plos.org
The opportunistic pathogen Pseudomonas aeruginosa chronically infects the lower airways
of patients with cystic fibrosis. Throughout the course of infection this organism undergoes …