[HTML][HTML] The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent

S Skopelja-Gardner, J An, J Tai, L Tanaka, X Sun… - Scientific reports, 2020 - nature.com
Most systemic lupus erythematosus (SLE) patients are photosensitive and ultraviolet B light
(UVB) exposure worsens cutaneous disease and precipitates systemic flares of disease …

[HTML][HTML] Neutrophils self-regulate immune complex-mediated cutaneous inflammation through CXCL2

JLY Li, CH Lim, FW Tay, CC Goh, S Devi… - Journal of Investigative …, 2016 - Elsevier
Deposition of immune complexes (ICs) in tissues triggers acute inflammatory pathology
characterized by massive neutrophil influx leading to edema and hemorrhage, and is …

[HTML][HTML] Lupus skin is primed for IL-6 inflammatory responses through a keratinocyte-mediated autocrine type I interferon loop

JN Stannard, TJ Reed, E Myers, L Lowe… - Journal of Investigative …, 2017 - Elsevier
Cutaneous lupus erythematosus is a disfiguring and common manifestation in systemic
lupus erythematosus, and the etiology of this predisposition for cutaneous inflammation is …

Sunlight triggers cutaneous lupus through a CSF-1-dependent mechanism in MRL-Faslpr mice

J Menke, MY Hsu, KT Byrne, JA Lucas… - The Journal of …, 2008 - journals.aai.org
Sunlight (UVB) triggers cutaneous lupus erythematosus (CLE) and systemic lupus through
an unknown mechanism. We tested the hypothesis that UVB triggers CLE through a CSF-1 …

Cutaneous lupus erythematosus: clinical aspects and molecular pathogenesis

V Oke, M Wahren‐Herlenius - Journal of internal medicine, 2013 - Wiley Online Library
Lupus erythematosus (LE) is an autoimmune disease with diverse clinical manifestations
ranging from limited cutaneous (CLE) to potentially life‐threatening systemic disease (SLE) …

[HTML][HTML] Human keratinocytes' response to injury upregulates CCL20 and other genes linking innate and adaptive immunity

M Kennedy-Crispin, E Billick, H Mitsui, N Gulati… - Journal of investigative …, 2012 - Elsevier
In the early stages of wound healing, keratinocytes (KCs) become “activated” and release
inflammatory molecules such as IL-1 and IL-8, which are linked to innate immune responses …

Impaired immunosuppressive response to ultraviolet radiation in interleukin-10–deficient mice

S Beissert, J Hosoi, R Kühn, K Rajewsky… - Journal of investigative …, 1996 - Elsevier
Exposure to mid-range ultraviolet radiation (UVR)[280–320 nm, ultraviolet B (UVB) radiation]
inhibits the acquisition of delayed-type hypersensitivity in mice and contact hypersensitivity …

Nonlesional lupus skin contributes to inflammatory education of myeloid cells and primes for cutaneous inflammation

AC Billi, F Ma, O Plazyo, M Gharaee-Kermani… - Science translational …, 2022 - science.org
Cutaneous lupus erythematosus (CLE) is a disfiguring and poorly understood condition
frequently associated with systemic lupus. Previous studies suggest that nonlesional …

[HTML][HTML] p38 Mitogen-Activated protein kinase mediates dual role of ultraviolet B radiation in induction of maturation and apoptosis of monocyte-derived dendritic cells

S Nakagawa, T Ohtani, M Mizuashi, ZUA Mollah… - Journal of investigative …, 2004 - Elsevier
Although ultraviolet B (UVB) induces apoptosis and functional perturbations in dendritic cells
(DC), for example, Langerhans cells (LC), it also stimulates some LC into maturation after …

Narrowband–UVB irradiation decreases the production of pro-inflammatory cytokines by stimulated T cells

H Sigmundsdottir, A Johnston, JE Gudjonsson… - Archives of …, 2005 - Springer
Narrow-band ultraviolet B (UVB) phototherapy is an effective treatment for psoriasis. Owing
to its limited penetration, the direct effects of UVB are mostly restricted to cells residing in the …