The dopamine D3 receptor (D3R) plays a prominent role in the modulation of cognition in
healthy individuals, as well as in the pathophysiological mechanism underlying the cognitive …

Currently available treatments have limited pro-cognitive effects for neuropsychiatric
disorders, such as schizophrenia, Parkinson's disease and Alzheimer's disease. The …

Dopamine D 3 receptors have a pre-and postsynaptic localization in brain stem nuclei,
limbic parts of the striatum, and cortex. Their widespread influence on dopamine release, on …

The prefrontal cortex is the area of the brain most closely associated with higher order
processes and the substrate for studies of mechanisms relevant to cognition. Cognition is …

The role of the D3 receptor has remained largely elusive before the development of
selective research tools, such as selective radioligands, antibodies, various highly specific …

Although dopamine D3 receptor antagonists have been shown to enhance frontocortical
cholinergic transmission and improve cognitive performance in rodents, data are limited and …

This review updates the existing knowledge suggesting a role for the D3 receptor in
schizophrenia and drug addiction. The D3 receptor is expressed in brain regions controlling …

Since their discovery in 1991, an extraordinary amount of information has accumulated
about the neurobiology and pharmacology of D4 receptors in the mammalian central …

Dopamine D3 receptors have eluded definitive linkage to neurologic and psychiatric
disorders since their cloning over 20 years ago. We report a new method that does not …

Dopamine (DA), as one of the major neurotransmitters in the central nervous system (CNS)
and periphery, exerts its actions through five types of receptors which belong to two major …