[HTML][HTML] The CD4+ T cell response to human cytomegalovirus in healthy and immunocompromised people

EY Lim, SE Jackson, MR Wills - Frontiers in cellular and infection …, 2020 - frontiersin.org
While CD8+ T cells specific for human cytomegalovirus (HCMV) have been extensively
studied in both healthy HCMV seropositive carriers and patients undergoing …

[HTML][HTML] Reconstitution of Human Cytomegalovirus–Specific CD4+ T Cells is critical for control of virus reactivation in hematopoietic stem cell transplant recipients but …

E Gabanti, D Lilleri, F Ripamonti, F Bruno… - Biology of Blood and …, 2015 - Elsevier
The relative contribution of human cytomegalovirus (HMCV)–specific CD4+ and CD8+ T
cells to the control of HCMV infection in hematopoietic stem cell transplant (HSCT) recipients …

Ex Vivo Profiling of CD8+-T-Cell Responses to Human Cytomegalovirus Reveals Broad and Multispecific Reactivities in Healthy Virus Carriers

R Elkington, S Walker, T Crough, M Menzies… - Journal of …, 2003 - Am Soc Microbiol
Human cytomegalovirus (HCMV) can establish both nonproductive (latent) and productive
(lytic) infections. Many of the proteins expressed during these phases of infection could be …

A fingerprint left by cytomegalovirus infection in the human T cell compartment

PJEJ van de Berg, A van Stijn, IJM Ten Berge… - Journal of clinical …, 2008 - Elsevier
Latent infection with human cytomegalovirus (HCMV) is accompanied by a strong increase
in the number of resting, effector-type CD4+ and CD8+ T cells with constitutive cytolytic …

Development of virus-specific CD4+ T cells during primary cytomegalovirus infection

RJ Rentenaar, LE Gamadia… - The Journal of …, 2000 - Am Soc Clin Investig
Although virus-specific CD4+ T cells have been characterized extensively in latently infected
individuals, it is unclear how these protective T-cell responses develop during primary virus …

Human Cytomegalovirus (HCMV)-Specific CD4+ T Cells Are Polyfunctional and Can Respond to HCMV-Infected Dendritic Cells In Vitro

SE Jackson, GX Sedikides, GM Mason… - Journal of …, 2017 - Am Soc Microbiol
Human cytomegalovirus (HCMV) infection and periodic reactivation are generally well
controlled by the HCMV-specific T cell response in healthy people. While the CD8+ T cell …

Diverse Specificities, Phenotypes, and Antiviral Activities of Cytomegalovirus-Specific CD8+ T Cells

SE Jackson, GM Mason, G Okecha… - Journal of …, 2014 - Am Soc Microbiol
ABSTRACT CD8+ T cells specific for pp65, IE1, and IE2 are present at high frequencies in
human cytomegalovirus (HCMV)-seropositive individuals, and these have been shown to …

Dynamics of CD4 and CD8 T cell responses to cytomegalovirus in healthy human donors

HS Dunn, DJ Haney, SA Ghanekar… - The Journal of …, 2002 - academic.oup.com
To study the dynamics of cytomegalovirus (CMV) immunity in healthy immunocompetent
hosts, interferon-γ–producing CD4 and CD8 T cell responses in the presence or absence of …

Simultaneous quantification of human cytomegalovirus (HCMV)‐specific CD4+ and CD8+ T cells by a novel method using monocyte‐derived HCMV‐infected …

L Lozza, D Lilleri, E Percivalle… - European journal of …, 2005 - Wiley Online Library
Immature dendritic cells (DC) infected with an endotheliotropic (Huv+) and leukotropic
(Leuk+) human cytomegalovirus (HCMV) strain were used as a stimulus to determine …

Molecular characterization of HCMV‐specific immune responses: Parallels between CD8+ T cells, CD4+ T cells, and NK cells

FA Vieira Braga, KML Hertoghs… - European journal of …, 2015 - Wiley Online Library
CD8+ T cells are important for immunity against human cytomegalovirus (HCMV). The
HCMV‐specific CD8+ T‐cell response is characterized by the accumulation of terminally …