Objective: To clarify the temporal relationship between systemic inflammation and
neurodegeneration, we examined whether a higher level of circulating inflammatory markers …

Objective To examine the association between systemic inflammation measured during
midlife and 20-year cognitive decline. Methods Within the Atherosclerosis Risk in …

Background: Systemic inflammation is associated with ischemia and Alzheimer disease
(AD). We hypothesized that inflammatory biomarkers would be associated with …

Background: Inflammation is linked to cognitive decline in midlife, but the neural basis for
this link is unclear. One possibility is that inflammation associates with adverse changes in …

Objective: The relation between inflammation and brain MRI findings in the elderly remains
poorly known. We investigated the association of circulating interleukin-6 (IL-6) and C …

Inflammatory models of neurodegeneration suggest that higher circulating levels of
inflammation can lead to cognitive decline. Despite established independent associations …

Background Chronic inflammation has been linked to memory and other cognitive
impairments, as well as Alzheimer's disease. Here, we investigate the association between …

Inflammatory processes may contribute to risk for Alzheimer's disease (AD) and age-related
brain degeneration. Metabolic and genetic risk factors, and physical activity may, in turn …

The aim of this investigation was to determine whether circulating inflammatory biomarkers c-
reactive protein (CRP), interleukin-6 (IL6), and alpha 1-antichymotrypsin (ACT) were related …

Background and Purpose—It is currently unclear whether midlife systemic inflammation
promotes the development of white matter (WM) abnormalities and small vessel disease in …