Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease

K Rajasekhar, T Govindaraju - RSC advances, 2018 - pubs.rsc.org
Alzheimer's disease (AD) is the most prevalent, progressive and multifaceted
neurodegenerative disorder associated with cognition, memory and behavioural …

Multifaceted Alzheimer's disease: Building a roadmap for advancement of novel therapies

D Kaur, T Behl, A Sehgal, S Singh, N Sharma… - Neurochemical …, 2021 - Springer
Alzheimer's disease (AD) is one of the most prevailing neurodegenerative disorders of
elderly humans associated with cognitive damage. Biochemical, epigenetic, and …

A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease

DK Lahiri, MR Farlow, K Sambamurti… - Current drug …, 2003 - ingentaconnect.com
Alzheimer's disease (AD), a progressive, degenerative disorder of the brain, is believed to
be the most common cause of dementia amongst the elderly. AD is characterized by the …

Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: a long-range point of view beyond 2020

H Hampel, S Lista, SJ Teipel, F Garaci, R Nisticò… - Biochemical …, 2014 - Elsevier
Recent advances in understanding the molecular mechanisms underlying various paths
toward the pathogenesis of Alzheimer's disease (AD) has begun to provide new insight for …

[HTML][HTML] Challenges for Alzheimer's disease therapy: insights from novel mechanisms beyond memory defects

RL Frozza, MV Lourenco, FG De Felice - Frontiers in neuroscience, 2018 - frontiersin.org
Alzheimer's disease (AD), the most common form of dementia in late life, will become even
more prevalent by midcentury, constituting a major global health concern with huge …

[HTML][HTML] Perspective insights into disease progression, diagnostics, and therapeutic approaches in Alzheimer's disease: a judicious update

AT Jan, M Azam, S Rahman, AMS Almigeiti… - Frontiers in aging …, 2017 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the progressive
accumulation of β-amyloid fibrils and abnormal tau proteins in and outside of neurons …

[HTML][HTML] Alzheimer mechanisms and therapeutic strategies

Y Huang, L Mucke - Cell, 2012 - cell.com
There are still no effective treatments to prevent, halt, or reverse Alzheimer's disease, but
research advances over the past three decades could change this gloomy picture. Genetic …

Alzheimer's disease: the challenge of the second century

DM Holtzman, JC Morris, AM Goate - Science translational medicine, 2011 - science.org
Alzheimer's disease (AD) was first described a little more than 100 years ago. It is the most
common cause of dementia with an estimated prevalence of 30 million people worldwide, a …

Concepts for the treatment of Alzheimer's disease: molecular mechanisms and clinical application

C Pietrzik, C Behl - International journal of experimental …, 2005 - Wiley Online Library
To date, various strategies have been developed in order to prevent or to slow down the
progression of Alzheimer's disease (AD). Despite the medical need for an effective …

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease

T Guo, D Zhang, Y Zeng, TY Huang, H Xu… - Molecular …, 2020 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …