Loss-of-function mutations in progranulin (GRN), a secreted glycoprotein expressed by
neurons and microglia, are a common autosomal dominant cause of frontotemporal …

Frontotemporal dementia (FTD) is a neurodegenerative disease with hallmark deficits in
social and emotional function. Heterozygous loss-of-function mutations in GRN, the …

Heterozygous loss-of-function mutations in progranulin (GRN) cause frontotemporal
dementia (FTD), a leading cause of early-onset dementia characterized clinically by …

Progranulin haploinsufficiency is a common cause of familial frontotemporal dementia
(FTD), but the role of progranulin in the brain is poorly understood. To investigate the role of …

Frontotemporal dementia (FTD) is typified by behavioral and cognitive changes manifested
as altered social comportment and impaired memory performance. To investigate the …

Loss‐of‐function mutations in progranulin (GRN) are a major autosomal dominant cause of
frontotemporal dementia (FTD), a neurodegenerative disorder in which social behavior is …

Frontotemporal dementia (FTD) is a neurodegenerative disease, leading to behavioral
changes and language difficulties. Heterozygous loss-of-function mutations in progranulin …

Loss-of-function mutations in progranulin, a lysosomal glycoprotein, cause
neurodegenerative disease. Progranulin haploinsufficiency causes frontotemporal dementia …

Frontotemporal lobar degeneration (FTLD) causes a spectrum of clinical presentations of
frontotemporal dementia (FTD), including progressive changes in behavior, personality …

Frontotemporal lobar degeneration (FTLD) is a devastating neurodegenerative disease that
is the second most common form of dementia affecting individuals under age 65. The most …