All bacterial superantigens use common structural strategies to bind to major
histocompatibility complex class II receptors, while binding the T cell antigen receptor in …

Just as we thought that we know everything about superantigens, new molecular and
structural studies indicate that we have only just begun to unravel the secrets of these …

Superantigens elicit massive and often destructive immune responses by circumventing the
usual rules of antigen presentation and T-cell recognition. Rather than binding to the cleft of …

In the face of the unique diversity and plasticity of the immune system pathogenic organisms
have developed multiple mechanisms in adaptation to their hosts, including the expression …

It has been 6 years since the novel concept of superantigen was proposed in 1989 in the
fields which cover immunology, microbiology and the study of infectious diseases (83) …

Superantigens are powerful microbial toxins that activate the immune system by binding to
class II major histocompatibility complex and T-cell receptor molecules. They cause a …

In the last 10 years many of the superantigens of the microbial world have been defined and
the mechanisms of cellular interaction between lymphocytes and antigen presenting cells …

Although the exact mechanisms by which superantigens may contribute to the pathogenesis
of diseases are unknown, it seems increasingly likely that they have a role in the induction …

It is well recognized that toxins of Staphylococcus aureus and Streptococcus pyogenes are
responsible for a wide range of clinical conditions, although their precise mode of action …

Superantigens are a class of immunostimulatory molecules produced by bacterla and
viruses. Their potent immune effects are due to their unique ability to bind to the major …