[HTML][HTML] Impaired autophagy in amyloid-beta pathology: A traditional review of recent Alzheimer's research

M Yuan, Y Wang, Z Huang, F Jing, P Qiao… - Journal of Biomedical …, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder. The major
pathological changes in AD progression are the generation and accumulation of amyloid …

Autophagy: a double-edged sword in Alzheimer's disease

YT Tung, BJ Wang, MK Hu, WM Hsu, H Lee… - Journal of …, 2012 - Springer
Autophagy is a major protein degradation pathway that is essential for stress-induced and
constitutive protein turnover. Accumulated evidence has demonstrated that amyloid-β (Aβ) …

Dual roles for autophagy: degradation and secretion of Alzheimer's disease Aβ peptide

P Nilsson, TC Saido - Bioessays, 2014 - Wiley Online Library
Alzheimer's disease (AD) is a neurodegenerative disease exhibiting amyloid beta (Aβ)
peptide accumulation as a key characteristic. Autophagy, which is dysregulated in AD …

Autophagy dysfunction in Alzheimer's disease

L Li, X Zhang, W Le - Neurodegenerative Diseases, 2010 - karger.com
Autophagy is a lysosome degradation pathway that turns over cytoplasmic materials and
helps the cell to maintain homeostasis. Usually, it is activated under conditions of nutrient …

Autophagy and Alzheimer's disease: from molecular mechanisms to therapeutic implications

MS Uddin, A Stachowiak, AA Mamun… - Frontiers in aging …, 2018 - frontiersin.org
Alzheimer's disease (AD) is the most common cause of progressive dementia in the elderly.
It is characterized by a progressive and irreversible loss of cognitive abilities and formation …

[HTML][HTML] Autophagy in Alzheimer's disease pathogenesis: Therapeutic potential and future perspectives

Z Zhang, X Yang, YQ Song, J Tu - Ageing research reviews, 2021 - Elsevier
Alzheimer's disease (AD) is a complex neurodegenerative disease in the elderly and the
most common cause of human dementia. AD is characterized by accumulation of abnormal …

New insights into autophagy dysfunction related to amyloid beta toxicity and neuropathology in Alzheimer's disease

C Ntsapi, D Lumkwana, C Swart, A du Toit… - International review of cell …, 2018 - Elsevier
The fine control of neuronal proteostasis is an essential element that preserves cell viability.
Advancing age is a major risk factor for Alzheimer's disease (AD), and autophagy is thought …

Molecular mechanism of autophagy: Its role in the therapy of Alzheimer's disease

Y Zhao, Y Zhang, J Zhang, X Zhang… - Current …, 2020 - ingentaconnect.com
Alzheimer's disease (AD) is a neurodegenerative disorder of progressive dementia that is
characterized by the accumulation of beta-amyloid (Aβ)-containing neuritic plaques and …

Proteostasis and neurodegeneration: a closer look at autophagy in Alzheimer's disease

H Barmaki, A Nourazarian… - Frontiers in Aging …, 2023 - frontiersin.org
Alzheimer's disease (AD) is characterized by the accumulation of misfolded amyloid-beta
and tau proteins. Autophagy acts as a proteostasis process to remove protein clumps …

The implications of autophagy in Alzheimer's disease

T Hamano, K Hayashi, N Shirafuji… - Current Alzheimer …, 2018 - ingentaconnect.com
The pathogenic mechanisms of Alzheimer's Disease (AD) involve the deposition of
abnormally misfolded proteins, amyloid β protein (Aβ) and tau protein. Aβ comprises senile …