The emergence and spread of Plasmodium falciparum parasites resistant to artemisinin
derivatives and their partners in southeastern Asia threatens malaria control and elimination …

Artemisinin-based combination therapies (ACTs) have been vital in reducing malaria
mortality rates since the 2000s. Their efficacy, however, is threatened by the emergence and …

Tanzania implemented artemether-lumefantrine (AL) as the first-line treatment for
uncomplicated malaria in November of 2006 because of resistance to sulfadoxine …

Abstract Background The Plasmodium falciparum chloroquine transporter gene (pfcrt) is
known to be involved in chloroquine and amodiaquine resistance, and more particularly the …

Malaria is a major public health problem in the Democratic Republic of Congo. Despite
progress achieved over the past decade in the fight against malaria, further efforts have to …

Background A report of the chloroquine and amodiaquine resistance pfcrt-SVMNT haplotype
in Tanzania raises concern about high-level resistance to the artesunate-amodiaquine …

Mutations in the chloroquine resistance transporter gene of Plasmodium falciparum (Pfcrt)
are associated with drug susceptibility status of chloroquine and other antimalarials that …

Background Resistance to anti-malarial drugs hinders efforts on malaria elimination and
eradication. Following the global spread of chloroquine-resistant parasites, the Republic of …

One of the major obstacles to malaria elimination in the world is the resistance in
Plasmodium falciparum to most antimalarial drugs. This study aimed to estimate the …

Background: Artemisinin-based combination therapies (ACTs) are the global mainstay
treatment of uncomplicated Plasmodium falciparum infections. PfMDR1 and PfCRT are two …