Abstract Genetic Renal Disease (GRD) presents to mainstream clinicians as a mixture of
kidney-specific as well as multi-organ entities, many with highly variable phenotype …

Most genetic disorders are clinically and genetically heterogeneous. Next-generation
sequencing (NGS) has revolutionized the field and is providing rapidly growing insights into …

Next-generation sequencing has dramatically decreased the cost of gene sequencing,
facilitating the simultaneous analysis of multiple genes at the same time; obtaining a genetic …

Nephrology practices currently are amidst a genetics/genomics revolution where clinical
molecular screening has transitioned from analysis of single genes (Sanger sequencing) to …

Clinical genetics is increasingly recognized as an important area within nephrology care.
Clinicians require awareness of genetic kidney disease to recognize clinical phenotypes …

The prevalence of end-stage renal disease (ESRD) and the number of kidney transplants
performed continues to rise every year, straining the procurement of deceased and living …

The growing accessibility and falling costs of genetic sequencing techniques has expanded
the utilization of genetic testing in clinical practice. For living kidney donation, genetic …

The expansion of genomic medicine is furthering our understanding of many human
diseases. This is well illustrated in the field of nephrology, through the characterization …

Technologies such as next-generation sequencing and chromosomal microarray have
advanced the understanding of the molecular pathogenesis of a variety of renal disorders …

Over the last decade, the search for gene variants with the potential to influence transplant
outcomes or predispose individuals to host–recipient-related phenotypes has generated a …