Peptide nucleic acids (PNA) are synthetic nucleic acid analogues with a neutral N-(2-
aminoethyl) glycine backbone. PNA possess unique physicochemical characteristics such …

Within the past couple of years peptide nucleic acid (PNA) antisense and antigene
technology has entered the realm of biological and preclinical studies. This is primarily due …

Peptide nucleic acids (PNA) are synthetic analog of DNA with a repeating N-(2-aminoethyl)-
glycine peptide backbone connected to purine and pyrimidine nucleobases via a linker …

[Frontiers in Bioscience, 4, d782-786, November 1, 1999] 782 ANTISENSE PROPERTIES OF
PEPTIDE NUCLEIC ACIDS Ursel Soomets, Mattia Page 1 [Frontiers in Bioscience, 4, d782-786 …

Peptide nucleic acid (PNA) is a DNA mimic based on a pseudopeptide (polyamide)
backbone. PNA oligomers bind strongly and with high sequence specificity to …

Peptide nucleic acids (PNA) are artificial structural mimics of nucleic acids capable of
sequence specific hybridization to both RNA and DNA. Thus they have obvious potential as …

Introduction: DNA/RNA-based drugs are considered of major interest in molecular diagnosis
and nonviral gene therapy. In this field, peptide nucleic acids (PNAs, DNA analogs in which …

Peptide Nucleic Acids (PNAs) are molecules combining structural features of proteins and
nucleic acid. They resemble DNA or RNA by forming helical polyamides containing nitrogen …

Aberrant gene expression is characteristic to all cancer cells and pathophysiology in
general. Selective inhibition of constitutively elevated expression of oncogenes provides an …

Peptide nucleic acid (PNA) is a non-ionic mimic of DNA that binds to complementary DNA
and RNA sequences with high affinity and selectivity. Targeting of single-stranded RNA …