Current heart failure (HF) therapy remains unable to substantially improve exercise capacity.
Studies have shown that exercise training has beneficial effects on the heart in both health …

Mitochondria are complex organelles essential for the production of energy. These dynamic,
complex organelles found in every cell and tissues of the body have been well-studied in …

The morbidity and mortality of cardiovascular diseases are exceedingly high worldwide.
Pathological heart remodeling, which is developed as a result of mitochondrial dysfunction …

Impaired skeletal muscle energetics could adversely affect physical and metabolic function
in patients with heart failure (HF). The effect of HF on aspects of mitochondrial structure and …

Aims Heart failure with reduced ejection fraction (HFrEF) induces skeletal muscle
mitochondrial abnormalities that contribute to exercise limitation; however, specific …

Abstract Changes in mitochondrial capacity and quality play a critical role in skeletal and
cardiac muscle dysfunction. In vivo measurements of mitochondrial capacity provide a clear …

Clinical consequences of heart failure are fatigue, dyspnea, and progressive impairment of
exercise tolerance. Regular exercise training is associated with health-improving effects. In …

BACKGROUND: We aimed to determine the role of skeletal muscle mitochondrial ATP
production rate (MAPR) in relation to exercise tolerance after resistance training (RT) in …

Impaired exercise capacity is the key symptom of heart failure (HF) and is associated with
reduced quality of life and higher mortality rates. Unfortunately, current therapies, although …

Using 31P-magnetic resonance spectroscopy during and after exercise, we studied whether
forearm metabolic responses to exercise were improved by 1 mo of training in 10 males with …