During recent years, RNA therapeutics have begun to make a substantial impact in the
clinic, with the approval of the siRNA-based therapeutic Patisiran in 2018, and of the two …

mRNA vaccines have recently proved to be highly effective against SARS-CoV-2. Key to
their success is the lipid-based nanoparticle (LNP), which enables efficient mRNA …

A mRNA vaccine is a type of vaccine that induces an immune response. Antigen-encoding
mRNA is delivered via vaccine carriers into the immune cells, which are produced because …

The lipid nanoparticle (LNP)-encapsulated, nucleoside-modified mRNA platform has been
used to generate safe and effective vaccines in record time against COVID-19. Here, we …

Messenger RNA vaccines lack specificity for dendritic cells (DCs)—the most effective cells at
antigen presentation. Here we report the design and performance of a DC-targeting virus …

A major determinant for the success of mRNA-based vaccines is the composition of the
nanoparticles (NPs) used for formulation and delivery. Cationic peptides represent …

The COVID-19 outbreak was a global pandemic with wide-ranging healthcare implications.
Although several mRNA-based vaccines delivered using lipid nanoparticles (LNP) have …

mRNA vaccines have recently received significant attention due to their role in combating
the SARS-CoV-2 pandemic. As a platform, mRNA vaccines have been shown to elicit strong …

The Omicron variant of SARS-CoV-2 recently swept the globe and showed high level of
immune evasion. Here, we generate an Omicron-specific lipid nanoparticle (LNP) mRNA …

Lipid nanoparticles (LNPs) are at the forefront of scientific thought due to the SARS-CoV-2
pandemic. While mRNA-LNPs have been studied for years, there is still much to be learned …