Microbe-Derived Indole Metabolite Demonstrates Potent Multidrug Efflux Pump Inhibition in Staphylococcus aureus
Efflux pumps are always at the forefront of bacterial multidrug resistance and account for the
failure of antibiotics. The present study explored the potential of 2-(2-Aminophenyl) indole …
failure of antibiotics. The present study explored the potential of 2-(2-Aminophenyl) indole …
Microbial efflux pump inhibitors: A journey around quinoline and indole derivatives
Antimicrobial resistance (AMR) is a complex threat to human health and, to date, it
represents a hot topic in drug discovery. The use of non-antibiotic molecules to block …
represents a hot topic in drug discovery. The use of non-antibiotic molecules to block …
Efflux pump inhibitory potential of indole derivatives as an arsenal against norA over-expressing Staphylococcus aureus
NorA, an extensively studied efflux pump in Staphylococcus aureus, has been connected to
fluoroquinolone, antiseptic, and disinfection resistance. Several studies have also …
fluoroquinolone, antiseptic, and disinfection resistance. Several studies have also …
In Vitro and In Silico Inhibition of Staphylococcus aureus Efflux Pump NorA by α-Pinene and Limonene
Since the discovery of the first antibiotics, bacteria have acquired a variety of resistance
mechanisms, with efflux pump (EP) being the most prominent mechanism for intracellular …
mechanisms, with efflux pump (EP) being the most prominent mechanism for intracellular …
Terpenes as bacterial efflux pump inhibitors: A systematic review
KJSDO Dias, GM Miranda, JR Bessa… - Frontiers in …, 2022 - frontiersin.org
Managing antibiotic resistance is a significant challenge in modern pharmacotherapy. While
molecular analyses have identified efflux pump expression as an essential mechanism …
molecular analyses have identified efflux pump expression as an essential mechanism …
[HTML][HTML] The 1, 8-naphthyridines sulfonamides are NorA efflux pump inhibitors
CD de Morais Oliveira-Tintino, DF Muniz… - Journal of Global …, 2021 - Elsevier
Objective Efflux pumps are transmembrane proteins associated with bacterial resistance
mechanisms. Bacteria use these proteins to actively transport antibiotics to the extracellular …
mechanisms. Bacteria use these proteins to actively transport antibiotics to the extracellular …
Antibiotic Potentiation Through Phytochemical-Based Efflux Pump Inhibitors to Combat Multidrug Resistance Bacteria
HS Cheema, A Maurya, S Kumar… - Medicinal …, 2024 - ingentaconnect.com
Background: Antimicrobial resistance development poses a significant danger to the efficacy
of antibiotics, which were once believed to be the most efficient method for treating infections …
of antibiotics, which were once believed to be the most efficient method for treating infections …
Promising FDA-approved drugs with efflux pump inhibitory activities against clinical isolates of Staphylococcus aureus
SAAM Abdel-Karim, AMA El-Ganiny, MA El-Sayed… - Plos one, 2022 - journals.plos.org
Background and objectives Staphylococcus aureus is an opportunistic pathogen that causes
wide range of nosocomial and community-acquired infections which have spread worldwide …
wide range of nosocomial and community-acquired infections which have spread worldwide …
Efflux pump inhibitors: a novel approach to combat efflux-mediated drug resistance in bacteria
Y Wang, H Venter, S Ma - Current drug targets, 2016 - ingentaconnect.com
The increasing multi-drug resistance has become a major threat to the public health.
Overexpression of multidrug efflux pumps is one of the major mechanisms of drug resistance …
Overexpression of multidrug efflux pumps is one of the major mechanisms of drug resistance …
Proteomic analysis of bacterial response to a 4-hydroxybenzylidene indolinone compound, which re-sensitizes bacteria to traditional antibiotics
Halogenated 4-hydroxybenzylidene indolinones have been shown to re-sensitize methicillin-
resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis …
resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis …